ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
3rd Edition
ISBN: 9781264013470
Author: McKinley
Publisher: MCGRAW-HILL LEARNING SOLN.(CC)
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Chapter 8.4, Problem 10WDL
What are some features that differ between female and male skulls?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 8 Solutions
ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
Ch. 8.1 - LEARNING OBJECTIVE
1. Compare and contrast the...Ch. 8.1 - What is the general function of the axial...Ch. 8.1 - Prob. 2LOCh. 8.1 - What is the difference between a foramen and a...Ch. 8.2 - LEARNING OBJECTIVE
3. Distinguish between the...Ch. 8.2 - Prob. 3WDLCh. 8.2 - Prob. 4LOCh. 8.2 - Prob. 5LOCh. 8.2 - Prob. 6LOCh. 8.2 - Prob. 1WDT
Ch. 8.2 - Prob. 4WDLCh. 8.2 - What bones form the middle cranial fossa, and...Ch. 8.2 - Prob. 7LOCh. 8.2 - Prob. 6WDLCh. 8.2 - Prob. 8LOCh. 8.2 - Prob. 9LOCh. 8.2 - Prob. 7WDLCh. 8.2 - In which four bones are the paranasal sinuses...Ch. 8.3 - Prob. 10LOCh. 8.3 - Prob. 11LOCh. 8.3 - Prob. 9WDLCh. 8.4 - Prob. 12LOCh. 8.4 - Prob. 2WDTCh. 8.4 - What are some features that differ between female...Ch. 8.4 - Prob. 13LOCh. 8.4 - Prob. 14LOCh. 8.4 - What are the two largest fontanelles, and when do...Ch. 8.5 - Prob. 15LOCh. 8.5 - Prob. 16LOCh. 8.5 - Prob. 12WDLCh. 8.5 - Prob. 17LOCh. 8.5 - LEARNING OBJECTIVES
18. Explain the sequence of...Ch. 8.5 - What are the secondary curves, and when do they...Ch. 8.5 - Prob. 19LOCh. 8.5 - Prob. 20LOCh. 8.5 - Prob. 3WDTCh. 8.5 - Compare the locations and functions of the...Ch. 8.5 - Prob. 15WDLCh. 8.6 - Prob. 21LOCh. 8.6 - Prob. 16WDLCh. 8.6 - Prob. 22LOCh. 8.6 - Prob. 23LOCh. 8.6 - Where specifically do the head and tubercle of a...Ch. 8.7 - Prob. 24LOCh. 8.7 - Prob. 25LOCh. 8.7 - Prob. 18WDLCh. 8.8 - Prob. 26LOCh. 8.8 - How do the sternal end and acromial end of the...Ch. 8.8 - Prob. 27LOCh. 8.8 - Prob. 20WDLCh. 8.9 - Prob. 28LOCh. 8.9 - Prob. 29LOCh. 8.9 - Prob. 21WDLCh. 8.9 - Prob. 22WDLCh. 8.9 - Prob. 30LOCh. 8.9 - Prob. 31LOCh. 8.9 - Prob. 32LOCh. 8.9 - Prob. 23WDLCh. 8.9 - Describe how the radius and ulna are positioned...Ch. 8.9 - Prob. 33LOCh. 8.9 - Prob. 34LOCh. 8.9 - List the eight carpal bones. Which of these bones...Ch. 8.10 - Prob. 35LOCh. 8.10 - LEARNING OBJECTIVES
36. Describe how the ossa...Ch. 8.10 - Prob. 37LOCh. 8.10 - WHAT DO YOU THINK?
4 Compare and contrast the...Ch. 8.10 - What three bones fuse to form the os coxae?Ch. 8.10 - Prob. 27WDLCh. 8.10 - Prob. 38LOCh. 8.10 - Prob. 39LOCh. 8.10 - How is the pelvic inlet distinguished from the...Ch. 8.10 - Prob. 40LOCh. 8.10 - Prob. 29WDLCh. 8.10 - Prob. 41LOCh. 8.10 - What are some differences in the symphysial...Ch. 8.11 - Prob. 42LOCh. 8.11 - Prob. 43LOCh. 8.11 - Prob. 44LOCh. 8.11 - Prob. 31WDLCh. 8.11 - Prob. 32WDLCh. 8.11 - Prob. 45LOCh. 8.11 - Prob. 46LOCh. 8.11 - Prob. 47LOCh. 8.11 - WHAT DO YOU THINK?
5 The medial and lateral...Ch. 8.11 - What are some bony features that are similar or...Ch. 8.11 - Prob. 34WDLCh. 8.11 - LEARNING OBJECTIVES
48. Locate and identify the...Ch. 8.11 - Prob. 49LOCh. 8.11 - Prob. 35WDLCh. 8.11 - Prob. 50LOCh. 8.11 - Prob. 36WDLCh. 8.12 - Prob. 51LOCh. 8.12 - Prob. 52LOCh. 8.12 - Prob. 37WDLCh. 8 - Prob. 1DYBCh. 8 - Which bone marking is matched with its correct...Ch. 8 - The frontal and parietal bones articulate at the...Ch. 8 - Prob. 4DYBCh. 8 - Prob. 5DYBCh. 8 - Prob. 6DYBCh. 8 - Prob. 7DYBCh. 8 - Prob. 8DYBCh. 8 - The femur articulates with the tibia at the a....Ch. 8 - Prob. 10DYBCh. 8 - Prob. 11DYBCh. 8 - Prob. 12DYBCh. 8 - What are the functions of the paranasal sinuses?Ch. 8 - Prob. 14DYBCh. 8 - Describe similarities and differences among true,...Ch. 8 - Compare and contrast the anatomic and functional...Ch. 8 - What are the primary similarities and differences...Ch. 8 - Prob. 18DYBCh. 8 - Prob. 19DYBCh. 8 - Prob. 20DYBCh. 8 - Prob. 1CALCh. 8 - Prob. 2CALCh. 8 - Prob. 3CALCh. 8 - Prob. 4CALCh. 8 - Use the following paragraph to answer questions...Ch. 8 - Prob. 1CSLCh. 8 - Prob. 2CSLCh. 8 - Forensic anthropologists are investigating...
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