Brock Biology of Microorganisms (14th Edition)
Brock Biology of Microorganisms (14th Edition)
14th Edition
ISBN: 9780321897398
Author: Michael T. Madigan, John M. Martinko, Kelly S. Bender, Daniel H. Buckley, David A. Stahl, Thomas Brock
Publisher: PEARSON
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Chapter 7.17, Problem 1MQ

What is feedback inhibition?

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.

Chapter 7 Solutions

Brock Biology of Microorganisms (14th Edition)

Ch. 7.5 - Prob. 2MQCh. 7.5 - Explain how the lac operon is both positively and...Ch. 7.6 - What is the major difference between...Ch. 7.6 - How do transcriptional activators in Archaea often...Ch. 7.7 - What are kinases and what is their role in...Ch. 7.7 - Prob. 2MQCh. 7.8 - What are the primary response regulator and the...Ch. 7.8 - Why is adaptation during chemotaxis important?Ch. 7.8 - How does the response of the chemortaxis system to...Ch. 7.9 - Prob. 1MQCh. 7.9 - Prob. 2MQCh. 7.10 - Prob. 1MQCh. 7.10 - Prob. 2MQCh. 7.10 - Prob. 3MQCh. 7.11 - How are different sets of genes expressed in the...Ch. 7.11 - Prob. 2MQCh. 7.12 - Why are the levels of DnaA protein controlled...Ch. 7.12 - Prob. 2MQCh. 7.14 - Prob. 1MQCh. 7.14 - Prob. 2MQCh. 7.15 - What happens when a riboswitch binds the small...Ch. 7.15 - What are the major differences between a repressor...Ch. 7.16 - Why does attenuation control not occur in...Ch. 7.16 - Prob. 2MQCh. 7.17 - What is feedback inhibition?Ch. 7.17 - Prob. 2MQCh. 7.18 - Prob. 1MQCh. 7.18 - Prob. 2MQCh. 7 - Prob. 1RQCh. 7 - Describe why a protein that binds to a specific...Ch. 7 - REVIEW QUESTIONS 3. Most biosynthetic operons need...Ch. 7 - What is the difference between an operon and a...Ch. 7 - Prob. 5RQCh. 7 - Prob. 6RQCh. 7 - Prob. 7RQCh. 7 - Adaptation allows the mechanism controlling...Ch. 7 - How can quorum sensing be considered a regulatory...Ch. 7 - Prob. 10RQCh. 7 - Prob. 11RQCh. 7 - Prob. 12RQCh. 7 - Prob. 13RQCh. 7 - Prob. 14RQCh. 7 - Prob. 15RQCh. 7 - Prob. 16RQCh. 7 - Prob. 17RQCh. 7 - Application Questions 1. What would happen to...Ch. 7 - Prob. 2AQCh. 7 - Prob. 3AQCh. 7 - Most of the regulatory systems described in this...Ch. 7 - Many amino acid biosynthetic operons under...Ch. 7 - How would you design a regulatory system to make...
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