WHAT IS LIFE? A GUIDE TO BIO 3E+LAUNCHPA
3rd Edition
ISBN: 9781319103316
Author: PHELAN
Publisher: Macmillan Higher Education
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Chapter 7, Problem 8MC
Summary Introduction
Introduction:
Pedigree analysis is a major tool in genetics. It is a family tree that maps the occurrence of a trait in a family for several generations.
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calculate the questions showing the solution including variables,unit and equations all the questiosn below using the data
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
QUESTION 8
For the following pedigree, assume that the mode of inheritance is X-linked recessive, and that the trait has full penetrance and expressivity and occurs at a very low frequency in the hum
population. Using XA for the dominant allele and Xa for the recessive allele, assign genotypes for the following individuals (if it is not possible to figure out the second allele of a genotype,
that with an underscore):
2
m
1
2
1
2
4 5 6
7
8
9
IV
1 2 3
5 6
7
8
CO
9
10
12 13
V
1,
2 3
4 5 6 7
8 9 10
11 12 13
a. Il-1:
b. 11-2:
c. III-3:
d. III-4:
e. If individuals IV-11 and IV-12 have another child, what is the probability that they will have a boy with the disorder?
Chapter 7 Solutions
WHAT IS LIFE? A GUIDE TO BIO 3E+LAUNCHPA
Ch. 7 - Prob. 1SACh. 7 - Prob. 2SACh. 7 - Prob. 3SACh. 7 - Prob. 4SACh. 7 - Prob. 5SACh. 7 - Prob. 6SACh. 7 - Prob. 7SACh. 7 - Prob. 8SACh. 7 - Prob. 9SACh. 7 - Prob. 10SA
Ch. 7 - Prob. 11SACh. 7 - Prob. 12SACh. 7 - Prob. 13SACh. 7 - Prob. 14SACh. 7 - Prob. 15SACh. 7 - Prob. 1MCCh. 7 - Prob. 2MCCh. 7 - Prob. 3MCCh. 7 - Prob. 4MCCh. 7 - Prob. 5MCCh. 7 - Prob. 6MCCh. 7 - Prob. 7MCCh. 7 - Prob. 8MCCh. 7 - Prob. 9MCCh. 7 - Prob. 10MCCh. 7 - Prob. 11MCCh. 7 - Prob. 12MCCh. 7 - Prob. 13MCCh. 7 - Prob. 14MCCh. 7 - Prob. 15MCCh. 7 - Prob. 16MC
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