Unit Operations Of Chemical Engineering
7th Edition
ISBN: 9789339213237
Author: MCCABE, WARREN
Publisher: Tata McGraw-Hill Education India
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Chapter 7, Problem 7.3P
Interpretation Introduction
Interpretation:
The change in pressure drop values due to variable void fraction is to be discussed.
Concept Introduction:
The pressure drop of packed bed depends on superficial velocity, particle diameter and size of packing used. This superficial velocity is the minimum velocity required to allow a pressure drop across a packed bed of known height and packing specifications. For small particles, this pressure drop does not require a sharp transition between the laminar and turbulent flows. Hence, for such cases, Ergun equation suffice such that the pressure drop is thought to be parabolic in nature and with critical velocity term only.
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Do question 9 please! Question 7 Is just there for reference!!
7) You are tasked with separating two proteins by ion exchange chromatography on a 30 cm long
column with an inner diameter of 2 cm. The resin has a diameter of 100 μm and a void fraction
of 0.3, and your mobile phase flows through the column at a rate of Q = 5 cm³/min. The Van
Deemter coefficients A, B, and C have been determined to be 0.0228 cm, 0.0036 cm²/min, and
0.00053 min, respectively, for both proteins. Protein A elutes from the column with an average
retention time of 27 min and standard deviation of 0.8 min. Protein B elutes from the column.
with an average retention time of 33.8 min and standard deviation of 1.0.
a) How many theoretical plates does the column contain?
b) What flow rate (Q) will give you the maximum resolution?
c) What is the minimum height of a theoretical plate for the system?
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Unit Operations Of Chemical Engineering
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