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6) Instead of moving bed adsorption, you decide to try fixed bed adsorption with a different resin for removal of your protein. Your column is 25 cm long with an inner diameter of 5 cm. The resin packed in the column has a density of 1.5 g/cm³ and a void fraction of 0.25. Equilibrium data suggests that the protein binding to the column follows a Langmuir isotherm with an Stot = 6.25 g protein/kg resin and Keq = 2.58 L broth/g protein. The feed contains 100 mg/L protein and flows through the column at 500 mL/h. The calculated binding capacity of the column under these conditions is 945 mg protein. a) After 17.7 h, you detect an unacceptable level of protein in the column effluent. What is the length of unused bed? b) After deciding that this process will work well for separation, you need to scale up to a 1 m long column with the same diameter. If all else but length of the column is held constant, how long will you be able to run the column before breakthrough?

6) Instead of moving bed adsorption, you decide to try fixed bed adsorption with a different resin for removal of your protein. Your column is 25 cm long with an inner diameter of 5 cm. The resin packed in the column has a density of 1.5 g/cm³ and a void fraction of 0.25. Equilibrium data suggests that the protein binding to the column follows a Langmuir isotherm with an Stot = 6.25 g protein/kg resin and Keq = 2.58 L broth/g protein. The feed contains 100 mg/L protein and flows through the column at 500 mL/h. The calculated binding capacity of the column under these conditions is 945 mg protein. a) After 17.7 h, you detect an unacceptable level of protein in the column effluent. What is the length of unused bed? b) After deciding that this process will work well for separation, you need to scale up to a 1 m long column with the same diameter. If all else but length of the column is held constant, how long will you be able to run the column before breakthrough?

Introduction to Chemical Engineering Thermodynamics
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
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6) Instead of moving bed adsorption, you decide to try fixed bed adsorption with a different resin for removal of your protein. Your column is 25 cm long with an inner diameter of 5 cm. The resin packed in the column has a density of 1.5 g/cm³ and a void fraction of 0.25. Equilibrium data suggests that the protein binding to the column follows a Langmuir isotherm with an Stot = 6.25 g protein/kg resin and Keq = 2.58 L broth/g protein. The feed contains 100 mg/L protein and flows through the column at 500 mL/h. The calculated binding capacity of the column under these conditions is 945 mg protein. a) After 17.7 h, you detect an unacceptable level of protein in the column effluent. What is the length of unused bed? b) After deciding that this process will work well for separation, you need to scale up to a 1 m long column with the same diameter. If all else but length of the column is held constant, how long will you be able to run the column before breakthrough?
Transcribed Image Text:6) Instead of moving bed adsorption, you decide to try fixed bed adsorption with a different resin for removal of your protein. Your column is 25 cm long with an inner diameter of 5 cm. The resin packed in the column has a density of 1.5 g/cm³ and a void fraction of 0.25. Equilibrium data suggests that the protein binding to the column follows a Langmuir isotherm with an Stot = 6.25 g protein/kg resin and Keq = 2.58 L broth/g protein. The feed contains 100 mg/L protein and flows through the column at 500 mL/h. The calculated binding capacity of the column under these conditions is 945 mg protein. a) After 17.7 h, you detect an unacceptable level of protein in the column effluent. What is the length of unused bed? b) After deciding that this process will work well for separation, you need to scale up to a 1 m long column with the same diameter. If all else but length of the column is held constant, how long will you be able to run the column before breakthrough?
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