Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 7, Problem 20P
In human DNA, 70% of cytosine residues that are followed by guanine (so-called CpG dinucleotides, where p indicates the phosphate in the phosphodiester bond between these two
| a. | Methylated CpG dinucleotides are hotspots for point mutations in human DNA. Explains why? | |
| b. | Making the simplifying assumptions that human DNA has an equal number of C–G and A–T base pairs, and that the human DNA sequence is random, how frequently in the human genome would you expect to find the base sequence CpG? | |
| c. | It turns out that, even after taking into account the actual GC content of human DNA (˜42%), the frequency of CpG in human DNA is much lower than predicted by the calculation in part (b). Explain why this might be the case. | |
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Chapter 7 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 7 - The following is a list of mutational changes. For...Ch. 7 - What explanations can account for the following...Ch. 7 - The DNA sequence of a gene from three...Ch. 7 - Among mammals, measurements of the rate of...Ch. 7 - Over a period of several years, a large hospital...Ch. 7 - Suppose you wanted to study genes controlling the...Ch. 7 - In a genetics lab, Kim and Maria infected a sample...Ch. 7 - The results of the fluctuation test Fig. 7.5 on p....Ch. 7 - The pedigree below shows the inheritance of a...Ch. 7 - Autism is a neurological disorder thought to be...
Ch. 7 - Remember that balancer chromosomes prevent the...Ch. 7 - In the experiment shown in Fig 7.13 on p. 218, H....Ch. 7 - Figure 7.14 on pp. 219-220 shows examples of base...Ch. 7 - So-called two-way mutagens can induce both a...Ch. 7 - In 1967, J. B. Jenkins treated wild-type male...Ch. 7 - Aflatoxin B1 is a highly mutagenic and...Ch. 7 - When a particular mutagen identified by the Ames...Ch. 7 - Prob. 18PCh. 7 - The Ames test uses the reversion rate his-/i to...Ch. 7 - In human DNA, 70 of cytosine residues that are...Ch. 7 - Albinism in animals is caused by recessive...Ch. 7 - Imagine that you caught a female albino mouse in...Ch. 7 - Plant breeders studying genes influencing leaf...Ch. 7 - In humans, albinism is normally inherited in an...Ch. 7 - Prob. 25PCh. 7 - a. You have a test tube containing 5 ml of a...Ch. 7 - Prob. 27PCh. 7 - The rosy ry gene of Drosophila encodes an enzyme...Ch. 7 - Prob. 29PCh. 7 - In a haploid yeast strain, eight recessive...Ch. 7 - The pathway for arginine biosynthesis in...Ch. 7 - In corn snakes, the wild-type color is brown. One...Ch. 7 - In a certain species of flowering plants with a...Ch. 7 - Prob. 34PCh. 7 - In each of the following cross schemes, two...Ch. 7 - Prob. 36PCh. 7 - The following complementing E. coli mutants were...Ch. 7 - In 1952, an article in the British Medical Journal...Ch. 7 - Mutations in an autosomal gene in humans cause a...Ch. 7 - Antibodies were made that recognize six proteins...Ch. 7 - Prob. 41PCh. 7 - Prob. 42PCh. 7 - In addition to the predominant adult hemoglobin,...Ch. 7 - Prob. 44PCh. 7 - Humans are normally trichromats; we have three...
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