
Concept explainers
To examine: Whether the statement “in terms of the way it interacts with DNA, the helix-loop-helix motif is more closely related to the leucine zipper motif than it is to the helix-turn-helix motif” is true or false.
Introduction:
A DNA-binding domain consists of a structural motif that recognizes a DNA sequence. The common motifs are helix-turn-helix, leucine zipper, helix-loop-helix, homeodomain, and zinc fingers.

Answer to Problem 1P
Correct answer: The statement is true.
Explanation of Solution
Helix-turn-helix motif is simple and constitutes two α helices connected by a short amino acid chain that forms the turn. Leucine zipper motif consists of two α helices joined together to constitute a short coil. They are bound together by interactions between hydrophobic side chains extending from a side of helix. Helix-loop-helix is similar to leucine zipper motif as it consists of a short α helix connected by a loop. The α helices in both leucine zipper proteins and helix-loop-helix proteins extend from the dimerization interface for the interaction with DNA. Thus, helix-loop-helix motif is more closely related to the leucine zipper motif.
Hence, the statement is true.
Want to see more full solutions like this?
Chapter 7 Solutions
Molecular Biology of the Cell (Sixth Edition)
- What is behavioral adaptarrow_forward22. Which of the following mutant proteins is expected to have a dominant negative effect when over- expressed in normal cells? a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function b. mutant Grb2 protein that cannot bind to RTK c. mutant RTK that lacks the extracellular domain d. mutant PDK that has the PH domain but lost the kinase function e. all of the abovearrow_forwardWhat is the label ?arrow_forward
- Can you described the image? Can you explain the question as well their answer and how to get to an answer to an problem like this?arrow_forwardglg 112 mid unit assignment Identifying melting processesarrow_forwardGive only the mode of inheritance consistent with all three pedigrees and only two reasons that support this, nothing more, (it shouldn't take too long)arrow_forward
- Oarrow_forwardDescribe the principle of homeostasis.arrow_forwardExplain how the hormones of the glands listed below travel around the body to target organs and tissues : Pituitary gland Hypothalamus Thyroid Parathyroid Adrenal Pineal Pancreas(islets of langerhans) Gonads (testes and ovaries) Placentaarrow_forward
- What are the functions of the hormones produced in the glands listed below: Pituitary gland Hypothalamus Thyroid Parathyroid Adrenal Pineal Pancreas(islets of langerhans) Gonads (testes and ovaries) Placentaarrow_forwardDescribe the hormones produced in the glands listed below: Pituitary gland Hypothalamus Thyroid Parathyroid Adrenal Pineal Pancreas(islets of langerhans) Gonads (testes and ovaries) Placentaarrow_forwardPlease help me calculate drug dosage from the following information: Patient weight: 35 pounds, so 15.9 kilograms (got this by dividing 35 pounds by 2.2 kilograms) Drug dose: 0.05mg/kg Drug concentration: 2mg/mLarrow_forward
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education





