Molecular Biology of the Cell (Sixth Edition)
6th Edition
ISBN: 9780815344322
Author: Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 7, Problem 5P
Summary Introduction
To mark: The sets of spots in the given figure that may represent proteins that differ by the number of phosphates they carry.
Concept introduction: Two-dimensional (2-D) gel electrophoresis contributes in analysis of protein mixtures. This method separates proteins in on the basis of two properties. The first dimension is isoelectric focusing that separates proteins according to their isoelectric points and second dimension is SDS-PAGE that separates proteins according to their molecular weights. Each protein in the mixture can be resolved in this way and the relative amount of protein can be evaluated.
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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.
b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake?
Options:
A. Dose; Increase dose
B. Dose; Decrease dose
C. Dose; Do not change dose
D. Interval; Increase the interval between doses (give the drug less frequently)
E. Interval; Decrease the interval between doses (give the drug more frequently)
F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
Chapter 7 Solutions
Molecular Biology of the Cell (Sixth Edition)
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