Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
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Chapter 6.4, Problem 1MI
Why is a lysogen considered a new or different strain of a given bacterial species?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.
Chapter 6 Solutions
Prescott's Microbiology
Ch. 6.2 - MICRO INQUIRY Which capsids are icosahedral? Which...Ch. 6.2 - MICRO INQUIRY Are the capsomers at the vertices of...Ch. 6.2 - MICRO INQUIRY Why is T4 said to have binal...Ch. 6.2 - Retrieve, Infer, Apply 1. How are viruses similar...Ch. 6.2 - Retrieve, Infer, Apply 2. What is the difference...Ch. 6.2 - Retrieve, Infer, Apply 3. Compare the structure of...Ch. 6.2 - Retrieve, Infer, Apply 4. What is an envelope?...Ch. 6.2 - Retrieve, Infer, Apply 5. All four nucleic acid...Ch. 6.2 - Retrieve, Infer, Apply 6. The RNA genomes of some...Ch. 6.3 - MICRO INQUIRY Which of these mechanisms involves...
Ch. 6.3 - MICRO INQUIRY Why do the empty capsids remain...Ch. 6.3 - Explain why the receptors that viruses have...Ch. 6.3 - What probably plays the most important role in...Ch. 6.3 - How do you think the complexity of the viral...Ch. 6.3 - In general, DNA viruses can be much more dependent...Ch. 6.3 - Consider the origin of viral envelopes and suggest...Ch. 6.3 - Why are the proteins involved in virion assembly...Ch. 6.4 - Why is a lysogen considered a new or different...Ch. 6.4 - Define the terms lysogeny, temperate phage,...Ch. 6.4 - What advantages might a phage gain by being...Ch. 6.4 - Describe lysogenic conversion and its...Ch. 6.4 - How does a latent infection differ from a chronic...Ch. 6.4 - What is a cytocidal infection? What is a...Ch. 6.4 - Define the following terms: tumor, neoplasia,...Ch. 6.4 - Distinguish the mechanism by which dsDNA viruses...Ch. 6.5 - Prob. 1MICh. 6.5 - Prob. 1RIACh. 6.5 - Given that viruses must be cultivated to make...Ch. 6.7 - What are viroids and why are they of great...Ch. 6.7 - How does a viroid differ from a virus? From a...Ch. 6.7 - What is a prion? In what way does a prion differ...Ch. 6.7 - Prob. 4RIACh. 6 - Many classification schemes are used to identify...Ch. 6 - The origin and evolution of viruses is...Ch. 6 - Consider the separate stages of an animal virus...Ch. 6 - Chronic wasting disease (CWD) is a...Ch. 6 - Syn5 is a virus that infects photosynthetic...
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