Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 6, Problem 6.8PS
QUANTITATIVE Turnover Number. Carbonic anhydrase catalyzes the reversible hydration of carbon dioxide to form bicarbonate ion:
As we will discover in Chapter 8, this reaction is important in the transport of carbon dioxide from body tissues to the lungs by red blood cells. Carbonic anhydrase has a molecular weight of 30,000 and a turnover number (kcat value) of 1 × 106 sec−1. Assume that you are given 1 mL of a solution containing 2.0 μg of pure carbonic anhydrase.
- (a) At what rate (in millimoles of CO2 consumed per second) will you expect this reaction to proceed under optimal conditions?
- (b) Assuming standard temperature and pressure, how much CO2 is that in mL per second?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 6 Solutions
Becker's World of the Cell (9th Edition)
Ch. 6 - Gasoline is highly combustible yet doesnt burst...Ch. 6 - How can an enzyme recognize and bind one specific...Ch. 6 - Prob. 1QCh. 6 - You work at a biotechnology company and are...Ch. 6 - Why do enzymes need to be regulated? By what...Ch. 6 - The Need for Enzymes. You should now be in a...Ch. 6 - Prob. 6.2PSCh. 6 - Prob. 6.3PSCh. 6 - Temperature and pH Effects. Figure 6-4 illustrates...Ch. 6 - MichaelisMenten Kinetics. Figure 6-16 represents a...
Ch. 6 - Prob. 6.6PSCh. 6 - QUANTITATIVE More Enzyme Kinetics. The galactose...Ch. 6 - QUANTITATIVE Turnover Number. Carbonic anhydrase...Ch. 6 - Inhibitors: Wrong Again. For each of the following...Ch. 6 - What Type of Inhibition? A new mucinase enzyme was...Ch. 6 - Prob. 6.11PSCh. 6 - Prob. 6.12PSCh. 6 - Prob. 6.13PS
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