Concepts of Genetics (11th Edition)
Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 6, Problem 28ESP

For the experiment in Problem 26, another gene, g, was studied. It demonstrated positive cotransformation when tested with gene f. Predict the results of testing gene g with genes a, b, c, d, and e.

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A wild-type mouse that is heterozygous for two immunoglobulin heavy chain alleles (IgHa/b) generates the population of B cells shown on the left of the figure below.  A mouse strain, also IgHa/b, carries an inactivating mutation in the VpreB gene. In addition to producing fewer mature B cells than the wild-type mice, the VpreB-deficient mice generate B cells as shown on the right.  What is the explanation of the difference seen between the wild-type and the VpreB-mutant B cells?
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Concepts of Genetics (11th Edition)

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