Telomeres and telomerases are required for replication of eukaryotic chromosomes and not for replication of circular bacterial chromosome with the help of diagram. Introduction : Both eukaryotes and prokaryotes have their DNA packed in chromosomes. Prokaryotic chromosomes are circular, and eukaryotic chromosomes are tightly packed and are linear. Eukaryotes have end-replication problem as their ends have telomeres and thus the DNA at ends of chromosomes are not fully copied at each round of replication. The single-stranded overhangs are produced from protective loops.

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Chapter 6, Problem 14Q

A.

Summary Introduction

To explain: Telomeres and telomerases are required for replication of eukaryotic chromosomes and not for replication of circular bacterial chromosome with the help of diagram.

Introduction: Both eukaryotes and prokaryotes have their DNA packed in chromosomes. Prokaryotic chromosomes are circular, and eukaryotic chromosomes are tightly packed and are linear. Eukaryotes have end-replication problem as their ends have telomeres and thus the DNA at ends of chromosomes are not fully copied at each round of replication. The single-stranded overhangs are produced from protective loops.

B.

Summary Introduction

To explain: Whether telomeres and telomerases would still be required to complete replication of eukaryotic chromosomes if primase laid down the RNA primer at the 3ʹ end of the lagging strand template.

Introduction: Both eukaryotes and prokaryotes have their DNA packed in chromosomes. Prokaryotic chromosomes are circular, and eukaryotic chromosomes are tightly packed and are linear. Eukaryotes have end-replication problem as their ends have telomeres and thus the DNA at ends of chromosomes are not fully copied at each round of replication. The single-stranded overhangs are produced from protective loops.

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