FUND. OF ANATOMY & PHYSIOLOGY F16 PKG
10th Edition
ISBN: 9781323431122
Author: Martini
Publisher: PEARSON C
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Chapter 6, Problem 10RQ
Summary Introduction
Introduction:
The loss of bone mass occurs with advancing age as the process of ossification (formation of bone tissue or bone remodelling) decreases with age.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 6 Solutions
FUND. OF ANATOMY & PHYSIOLOGY F16 PKG
Ch. 6 - Name the major functions of the skeletal system.Ch. 6 - Identify the categories used for classifying a...Ch. 6 - Define bone markings.Ch. 6 - Prob. 4CPCh. 6 - How would the compressive strength of a bone be...Ch. 6 - If the activity of osteoclasts exceeds the...Ch. 6 - Prob. 7CPCh. 6 - Prob. 8CPCh. 6 - In endochondral ossification, what is the original...Ch. 6 - Prob. 10CP
Ch. 6 - How could x-rays of the femur be used to determine...Ch. 6 - Describe bone remodeling.Ch. 6 - Prob. 13CPCh. 6 - Prob. 14CPCh. 6 - Prob. 15CPCh. 6 - Prob. 16CPCh. 6 - Prob. 17CPCh. 6 - Why does a child who has rickets have difficulty...Ch. 6 - List the four steps involved in fracture repair,...Ch. 6 - Prob. 19CPCh. 6 - Prob. 22CPCh. 6 - Prob. 20CPCh. 6 - Define osteopenia.Ch. 6 - Prob. 24CPCh. 6 - Prob. 1RQCh. 6 - Prob. 2RQCh. 6 - Prob. 3RQCh. 6 - The basic functional unit of compact bone is the...Ch. 6 - The vitamins essential for normal adult bone...Ch. 6 - Prob. 6RQCh. 6 - Prob. 7RQCh. 6 - Prob. 8RQCh. 6 - Prob. 9RQCh. 6 - Prob. 10RQCh. 6 - Name the major functions of the skeletal system.Ch. 6 - Prob. 12RQCh. 6 - Prob. 13RQCh. 6 - Prob. 14RQCh. 6 - Prob. 15RQCh. 6 - Prob. 16RQCh. 6 - Prob. 17RQCh. 6 - Prob. 18RQCh. 6 - If spongy bone has no osteons, how do nutrients...Ch. 6 - Prob. 20RQCh. 6 - Prob. 21RQCh. 6 - What are the functional relationships between the...Ch. 6 - Prob. 23RQCh. 6 - Prob. 24RQCh. 6 - Prob. 25RQCh. 6 - How might bone markings be useful in identifying...Ch. 6 - While playing on her swing set, 10-year-old Sally...Ch. 6 - Prob. 28RQCh. 6 - Prob. 29RQCh. 6 - In physical anthropology, cultural conclusions can...Ch. 6 - Prob. 1CCCh. 6 - Identify the categories used for classifying a...
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