Campbell Biology Plus Masteringbiology
10th Edition
ISBN: 9780321775849
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Chapter 56, Problem 56.4CR
Summary Introduction
To analyze: The reason to choose a healthier way to feed at a lower or a higher trophic level due to biological magnification caused by the accumulation of toxins.
Introduction: The study of the life cycle includes the effect of the accumulation of the toxic effects of pesticides at each trophic level of the biological chain. The first organisms include the bacteria and other microorganisms, which
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 56 Solutions
Campbell Biology Plus Masteringbiology
Ch. 56.1 - Explain why it is too narrow to define the...Ch. 56.1 - Identify the four main threats to biodiversity and...Ch. 56.1 - WHAT IF? Imagine two populations of a fish...Ch. 56.2 - How does the reduced genetic diversity of small...Ch. 56.2 - If there were 100 greater prairie chickens in a...Ch. 56.2 - WHAT IF? In 2005, at least ten grizzly bears in...Ch. 56.3 - Prob. 1CCCh. 56.3 - Prob. 2CCCh. 56.3 - Prob. 3CCCh. 56.4 - How can the addition of excess mineral nutrients...
Ch. 56.4 - Prob. 2CCCh. 56.4 - MAKE CONNECTIONS Mutagens are chemical and...Ch. 56.5 - What is meant by the term sustainable development?Ch. 56.5 - Prob. 2CCCh. 56.5 - WHAT IF? Suppose a new fishery is discovered, and...Ch. 56 - Give at least three examples of key ecosystem...Ch. 56 - Why is the minimum viable population size smaller...Ch. 56 - Prob. 56.3CRCh. 56 - Prob. 56.4CRCh. 56 - Prob. 56.5CRCh. 56 - One characteristic that distinguishes a population...Ch. 56 - The main cause of the increase in the amount of...Ch. 56 - Prob. 3TYUCh. 56 - Which of the following is a consequence of...Ch. 56 - Which of the following strategies would most...Ch. 56 - Of the following statements about protected areas...Ch. 56 - Prob. 7TYUCh. 56 - Prob. 8TYUCh. 56 - Prob. 9TYUCh. 56 - WRITE ABOUT A THEME: INTERACTIONS One factor...Ch. 56 - Prob. 11TYU
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