Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 54.2, Problem 2SB
What environmental factors influence rates of primary productivity in terrestrial and aquatic ecosystems?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 54 Solutions
Biology: The Dynamic Science (MindTap Course List)
Ch. 54.1 - In the generalized compartment model of...Ch. 54.1 - Prob. 2SBCh. 54.1 - Prob. 3SBCh. 54.2 - What is the difference between gross primary...Ch. 54.2 - What environmental factors influence rates of...Ch. 54.2 - Why is energy lost from an ecosystem at every...Ch. 54.2 - Prob. 4SBCh. 54.3 - Prob. 1SBCh. 54.3 - Prob. 2SBCh. 54.3 - Prob. 3SB
Ch. 54.3 - What is Earths main reservoir for phosphorus, and...Ch. 54.4 - Prob. 1SBCh. 54.4 - Prob. 2SBCh. 54.4 - Prob. 3SBCh. 54 - Prob. 1TYKCh. 54 - The total dry weight of plant material in a forest...Ch. 54 - Prob. 3TYKCh. 54 - Prob. 4TYKCh. 54 - Which process moves nutrients from the available...Ch. 54 - Which of the following materials has a sedimentary...Ch. 54 - Prob. 7TYKCh. 54 - Prob. 8TYKCh. 54 - The amount of energy available at the highest...Ch. 54 - Which of the following statements is supported by...Ch. 54 - Prob. 11TYKCh. 54 - Prob. 12TYKCh. 54 - Prob. 13TYKCh. 54 - Prob. 14TYKCh. 54 - Prob. 15TYKCh. 54 - Prob. 16TYKCh. 54 - Prob. 1ITD
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