Biology
4th Edition
ISBN: 9781259188121
Author: Peter Stiling, Robert Brooker, Linda Graham, Eric Widmaier
Publisher: McGraw-Hill Education
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Chapter 5.3, Problem 1CC
Summary Introduction
To explain: The process of the transfer of phospholipids to the leaflet of the ER membrane facing towards the ER lumen.
Introduction: The phospholipid bilayer is formed in a particular arrangement where its hydrophobic ends are away from the aqueous medium. The phospholipids have their polar hydrophilic head towards the outward side while hiding the hydrophobic parts in between. This configuration is energetically favorable and hence aids to the stability of the membrane.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 5 Solutions
Biology
Ch. 5.1 - Prob. 1CCCh. 5.2 - Prob. 1CCCh. 5.2 - Prob. 2CCCh. 5.2 - Prob. 1BCCh. 5.3 - Prob. 1CCCh. 5.3 - Prob. 2CCCh. 5.4 - Prob. 1BCCh. 5.4 - Which molecule would you expect to pass through a...Ch. 5.4 - Prob. 2BCCh. 5.4 - Lets suppose the inside of a cell has a solute...
Ch. 5.5 - What is the purpose of gating?Ch. 5.5 - Prob. 1EQCh. 5.5 - Prob. 2EQCh. 5.5 - Prob. 3EQCh. 5.5 - Prob. 2CCCh. 5.6 - What is the function of the protein coat?Ch. 5 - Prob. 1TYCh. 5 - Which of the following events can never be...Ch. 5 - Lets suppose an insect, which doesnt maintain a...Ch. 5 - Prob. 4TYCh. 5 - Prob. 5TYCh. 5 - Prob. 6TYCh. 5 - Prob. 7TYCh. 5 - Prob. 8TYCh. 5 - Prob. 9TYCh. 5 - Large particles or large volumes of fluid can be...Ch. 5 - With your textbook closed, draw and describe the...Ch. 5 - Prob. 2CQCh. 5 - Prob. 3CQCh. 5 - Prob. 1COQCh. 5 - With regard to bringing solutes into the cell...
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