IA MODIFIED MASTERING BIOLOGY WITH E TEX
12th Edition
ISBN: 9780136781752
Author: Urry
Publisher: PEARSON
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Chapter 50.3, Problem 2CC
Summary Introduction
To determine: The effect of presbyopia on a person’s vision.
Concept introduction:
Presbyopia is an eye defect where the eye lens loses its elasticity and attains a flat shape. It is generally found in the old people.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 50 Solutions
IA MODIFIED MASTERING BIOLOGY WITH E TEX
Ch. 50.1 - Prob. 1CCCh. 50.1 - Prob. 2CCCh. 50.1 - Prob. 3CCCh. 50.2 - How are otoliths adaptive for burrowing mammals,...Ch. 50.2 - Prob. 2CCCh. 50.2 - Prob. 3CCCh. 50.2 - Prob. 4CCCh. 50.3 - Contrast the light-detecting organs of planarians...Ch. 50.3 - Prob. 2CCCh. 50.3 - Prob. 3CC
Ch. 50.3 - Prob. 4CCCh. 50.4 - Explain why some taste receptor cells arid all...Ch. 50.4 - Prob. 2CCCh. 50.4 - Prob. 3CCCh. 50.5 - Contrast the role of Ca2+ in the contraction of a...Ch. 50.5 - Prob. 2CCCh. 50.5 - Prob. 3CCCh. 50.6 - Contrast swimming and flying in terms of the main...Ch. 50.6 - MAKE CONNECTIONS. Peristalsis contributes to the...Ch. 50.6 - WHAT IF? When using your arms to lower yourself...Ch. 50 - Sensory receptors transduce stimulus energy and...Ch. 50 - How are music volume and pitch encoded in signals...Ch. 50 - Prob. 50.3CRCh. 50 - Prob. 50.4CRCh. 50 - What are two major functions of ATP hydrolysis in...Ch. 50 - Which of the following sensory receptors is...Ch. 50 - The middle ear converts (A) air pressure waves to...Ch. 50 - Prob. 2TYUCh. 50 - Prob. 3TYUCh. 50 - Prob. 4TYUCh. 50 - Although some sharks close their eyes just before...Ch. 50 - Prob. 6TYUCh. 50 - EVOLUTION CONNECTION In general, locomotion on...Ch. 50 - Prob. 8TYUCh. 50 - WRITE ABOUT A THEME: ORGANIZATION In a short essay...Ch. 50 - SYNTHESIZE YOUR KNOWLEDGE Bloodhounds, which are...Ch. 50 - If an egg rolls out of the nest, a mother greylag...
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