Essential Cell Biology
Essential Cell Biology
4th Edition
ISBN: 9780815344544
Author: Keith Roberts, Karen Hopkin, Alexander D Johnson, Martin Raff, Dennis Bray, Bruce Alberts, Julian Lewis, Peter Walter
Publisher: TAYLOR
bartleby

Concept explainers

bartleby

Videos

Question
Book Icon
Chapter 5, Problem 8Q
Summary Introduction

To explain: The melting nature of the three given DNA strands.

Concept introduction: A DNA molecule is made up of a helical strand composed of nucleotide base pairs carrying the genetic instructions used in the growth, development, functioning, and reproduction of all living organisms. When two strands of DNA come together, they form hydrogen bongs between the complementary bases present in each chain. Bond formation releases considerable amount of energy and thus contributes to an increase in entropy of the DNA molecule. Adenine and thymine residues are bonded by two hydrogen bonds between them, whereas cytosine and guanine bases are by three hydrogen bonds. Therefore, the energy required for the dissociation of two strands of a DNA primarily depends on the number of A-T and C-G base pairs.

Blurred answer
Students have asked these similar questions
Outline a method for using apomixis to maintain feminized CannabisAssume apomixis is controlled by a single dominant gene. You can choose the type of apomixis: obligate or facultative, gametophytic or sporophytic. Discuss advantages and disadvantages of your proposed method.
Kinetics: One-Compartment First-Order Absorption 1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.  Using this data and set of graphs, determine:(calculate for each variable) (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e)absolute ip bioavailability, Fip  (f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L.  Measurements from preliminary tests indicate the following human pharmacokinetic parameter values:  t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%.  Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug: (a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate) (b) Estimate the time for maximum plasma concentration (tmax).  (c) Estimate the maximum plasma concentration (Cmax).  (d) Estimate the time at which the plasma level first rises above 30 mg/L.  (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L.  Hint:  based on part (a) it should be apparent that the answer is less than 1hr.)  (e)…
Knowledge Booster
Background pattern image
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Text book image
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Text book image
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Text book image
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Molecular Techniques: Basic Concepts; Author: Dr. A's Clinical Lab Videos;https://www.youtube.com/watch?v=7HFHZy8h6z0;License: Standard Youtube License