Concept explainers
To explain: What would happen if A-C, A-G pairs formed during
Introduction: According to Chargaff’s rule, DNA of all organisms should have an equal ratio (1:1 ratio) of its pyrimidine and purine bases. That is, the amount of guanine should be equaled to cytosine and the amount of adenine should be equaled to thymine. In order to achieve this, adenine always pairs with thymine and guanine with cytosine only. In case if any bases undergo pairing with a different base, it would seriously affect the accuracy of inheritance and the structure formed so would be energetically unstable.
To explain: Why inappropriate bases are often not incorporated in the DNA.
Introduction: According to Chargaff’s rule, DNA of all organisms should have an equal ratio (1:1 ratio) of its pyrimidine and purine bases. That is, the amount of guanine should be equaled to cytosine and the amount of adenine should be equaled to thymine. In order to achieve this, adenine always pairs with thymine and guanine with cytosine only. In case if any bases undergo pairing with a different base, it would seriously affect the accuracy of inheritance and the structure formed so would be energetically unstable.
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