Essential Cell Biology
Essential Cell Biology
4th Edition
ISBN: 9780815344544
Author: Keith Roberts, Karen Hopkin, Alexander D Johnson, Martin Raff, Dennis Bray, Bruce Alberts, Julian Lewis, Peter Walter
Publisher: TAYLOR
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Chapter 5, Problem 6Q
Summary Introduction

To explain: What would happen if A-C, A-G pairs formed during DNA replication and the inappropriate bases were incorporated.

Introduction: According to Chargaff’s rule, DNA of all organisms should have an equal ratio (1:1 ratio) of its pyrimidine and purine bases. That is, the amount of guanine should be equaled to cytosine and the amount of adenine should be equaled to thymine. In order to achieve this, adenine always pairs with thymine and guanine with cytosine only. In case if any bases undergo pairing with a different base, it would seriously affect the accuracy of inheritance and the structure formed so would be energetically unstable.

Summary Introduction

To explain: Why inappropriate bases are often not incorporated in the DNA.

Introduction: According to Chargaff’s rule, DNA of all organisms should have an equal ratio (1:1 ratio) of its pyrimidine and purine bases. That is, the amount of guanine should be equaled to cytosine and the amount of adenine should be equaled to thymine. In order to achieve this, adenine always pairs with thymine and guanine with cytosine only. In case if any bases undergo pairing with a different base, it would seriously affect the accuracy of inheritance and the structure formed so would be energetically unstable.

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