EP CONNECT ONLINE ACCESS FOR BIOLOGY
20th Edition
ISBN: 9781260494655
Author: Raven
Publisher: MCG COURSE
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Textbook Question
Chapter 5, Problem 2U
What chemical property characterizes the interior of the phospholipid bilayer?
a. It is hydrophobic.
b. It is hydrophilic.
c. It is polar.
d. It is saturated.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 5 Solutions
EP CONNECT ONLINE ACCESS FOR BIOLOGY
Ch. 5.1 - Prob. 1LOCh. 5.1 - Explain the fluid mosaic model of membrane...Ch. 5.2 - List the different components of phospholipids.Ch. 5.2 - Prob. 2LOCh. 5.2 - Prob. 3LOCh. 5.3 - Illustrate the functions of membrane proteins.Ch. 5.3 - Prob. 2LOCh. 5.3 - Prob. 3LOCh. 5.4 - Compare simple diffusion and facilitated...Ch. 5.4 - Prob. 2LO
Ch. 5.4 - Prob. 3LOCh. 5.5 - Prob. 1LOCh. 5.5 - Prob. 2LOCh. 5.5 - Prob. 3LOCh. 5.6 - Distinguish between endocytosis and exocytosis.Ch. 5.6 - Illustrate how endocytosis can be specific.Ch. 5 - According to the fluid mosaic model, membranes are...Ch. 5 - Prob. 2IQCh. 5 - The fluid mosaic model of the membrane describes...Ch. 5 - What chemical property characterizes the interior...Ch. 5 - The transmembrane domain of an integral membrane...Ch. 5 - The specific function of a membrane within a cell...Ch. 5 - The movement of water across a membrane is...Ch. 5 - Prob. 6UCh. 5 - Which of the following is NOT a mechanism for...Ch. 5 - A bacterial cell that can alter the composition of...Ch. 5 - What variable(s) influence(s) whether a nonpolar...Ch. 5 - Which of the following does NOT contribute to the...Ch. 5 - How are active transport and coupled transport...Ch. 5 - A cell can use the process of facilitated...Ch. 5 - figure 5.5 describes a classic experiment...Ch. 5 - Each compartment of the endomembrane system of a...Ch. 5 - The distribution of lipids in the ER membrane is...
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