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Fundamentals of Anatomy & Physiology Plus Mastering A&P with eText - Access Card Package (10th Edition) (New A&P Titles by Ric Martini and Judi Nath)
10th Edition
ISBN: 9780321908599
Author: Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew
Publisher: PEARSON
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Question
Chapter 5, Problem 27CP
Summary Introduction
To determine:
The term used to describe the thickened stratum corneum underlying the free edge of a nail.
Concept introduction:
The exposed surface of the skin is called as the stratum corneum. There are many layers of the stratum corneum forming the skin layer. The number of the layers vary from 15-30. The term used to define the region below the thickened stratum corneum underneath the free edge of a nail is called as “hyponychium”.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 5 Solutions
Fundamentals of Anatomy & Physiology Plus Mastering A&P with eText - Access Card Package (10th Edition) (New A&P Titles by Ric Martini and Judi Nath)
Ch. 5 - Identity the layers of the epidermis.Ch. 5 - Dandruff is caused by excessive shedding of cells...Ch. 5 - A splinter that penetrates to the third layer of...Ch. 5 - Why does taking a bath cause wrinkly fingertips...Ch. 5 - Some criminals sand the Lips of their fingers so...Ch. 5 - Prob. 11CPCh. 5 - Prob. 13CPCh. 5 - Prob. 14CPCh. 5 - Prob. 15CPCh. 5 - Prob. 16CP
Ch. 5 - Prob. 12CPCh. 5 - Prob. 18CPCh. 5 - Prob. 17CPCh. 5 - Name the two major pigments in the epidermis.Ch. 5 - Why does exposure to sunlight darken skin?Ch. 5 - Prob. 8CPCh. 5 - Prob. 9CPCh. 5 - Prob. 10CPCh. 5 - Describe a typical strand of hair.Ch. 5 - What happens when the arrector pili muscle...Ch. 5 - Once a burn on the forearm that destroys the...Ch. 5 - Prob. 22CPCh. 5 - Prob. 23CPCh. 5 - Prob. 24CPCh. 5 - Which type of skin gland is most affected by the...Ch. 5 - Prob. 26CPCh. 5 - Prob. 27CPCh. 5 - Prob. 28CPCh. 5 - Prob. 29CPCh. 5 - Why can skin regenerate effectively even after...Ch. 5 - Prob. 31CPCh. 5 - Why does hair turn while or gray with age?Ch. 5 - Prob. 1RQCh. 5 - The two major components of the integumentary...Ch. 5 - Prob. 3RQCh. 5 - Prob. 4RQCh. 5 - Prob. 5RQCh. 5 - Prob. 6RQCh. 5 - Prob. 7RQCh. 5 - The accessory structures of the integument include...Ch. 5 - Prob. 9RQCh. 5 - Prob. 10RQCh. 5 - Prob. 11RQCh. 5 - The primary function of sensible perspiration is...Ch. 5 - Prob. 13RQCh. 5 - Prob. 14RQCh. 5 - Prob. 15RQCh. 5 - Prob. 16RQCh. 5 - Prob. 17RQCh. 5 - What two major layers constitute the dermis, and...Ch. 5 - List the four phases in the regeneration of the...Ch. 5 - Contrast insensible perspiration and sensible...Ch. 5 - Prob. 21RQCh. 5 - Prob. 22RQCh. 5 - Prob. 23RQCh. 5 - Prob. 24RQCh. 5 - Prob. 25RQCh. 5 - Prob. 26RQCh. 5 - Prob. 27RQCh. 5 - Prob. 28RQCh. 5 - Prob. 29RQCh. 5 - One of the factors to which lie detectors respond...Ch. 5 - Prob. 31RQCh. 5 - Prob. 1CCCh. 5 - Prob. 2CC
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