Concept explainers
To determine: The main actions of renin-angiotensin-aldosterone pathway.
Introduction: The kidney is an important organ of the excretory system, and nephron is the basic structural unit of kidney. The main function of nephron is ultrafiltration. It removes waste products, ions, and excess water from the blood, and returns the required molecules back to the blood. The glomerular filtration rate (GFR) refers to the rate of flow of filtered fluid through the kidney.
To compare: The main actions of this pathway with the actions of atrial natriuretic peptide (ANP).
Introduction: Blood pressure is the force that moves the blood through the circulatory system. Angiotensin, antidiuretic hormone, aldosterone, and atrial natriuretic peptide are hormones that participate in regulating the blood pressure.
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- Renin is secreted in response to hypovolemia or to an increase in the osmolality of the blood. Provide three possible mechanisms by which these conditions may stimulate rennin secretion. What are the consequences of increased rennin secretion that lead to increased aldosterone secretion? Present this sequence of events. Why are angiotensin converting enzyme inhibitors (ACEIs) used as a common therapy for hypertension? How do they influence blood pressure? Are plasma levels of renin elevated or depressed in a patient with Conn’s disease? Why?arrow_forwardDescribe how ANP is regulated and how it opposes the action of the other three hormones (angiotensin II, ADH, and aldosterone).arrow_forwardDescribe the Angiotensinogen-Angiotensin I-Angiotensin II Mechanism?arrow_forward
- Give the steps in the renin angiotensin pathway from start to finish.arrow_forwardExplain the mechanism how furosemide affects kidney tubules. How does this affect K+ balance? How different is the mechanism of thiazide affect urine production? Describe the process of acid-base regulation in human body.arrow_forwardInsulin and aldosterone play an essential role in the regulation of potassium distribution between the intracellular and extracellular fluid compartments. Discuss the effect of a deficiency in these two hormones on internal potassium distributionarrow_forward
- Spironolactone is a widely prescribed diuretic ("water pill" - make you pee) which works by acting as an antagonist to aldosterone thus blocking its actions. Knowing this, how does spironolactone work as an antihypertensive (lower BP) and as a "potassium-sparing" diuretic?arrow_forwarda. A person ingests an ion-channel inhibitor, such that the ion channels present in the Loop of Henle are only able to pump at half their normal rate? b. What would this person notice about changes to their physiological filtration? (Answer a and b)arrow_forwardANP (atrial natriuretic peptide) can be considered to act against (in opposition to) the reninangiotensin-aldosterone-system (RAAS). What then does ANP try to achieve?arrow_forward
- describe the endocrine system of angiotensinogen > angiotensin 1 > angiotensin 2arrow_forwardWrite the summary of the renin-angiotensin system and the stimulation of aldosterone secretion by angiotensin II?arrow_forwardExplain how the capacity (function) of the sodium potassium pumps found in the ascending loop of Henle enable the establishment of the medullary concentration gradient.arrow_forward
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