Biology: The Unity and Diversity of Life (MindTap Course List)
14th Edition
ISBN: 9781305073951
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Textbook Question
Chapter 46, Problem 5SQ
Efficiency of energy transfers in aquatic ecosystem is typically higher than in land ecosystems because ______.
- a. aquatic food webs include more endotherms
- b. algae do not make lignin
- c. primary production cannot occur in water
- d. all of the above
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 46 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 46 - In most ecosystems, the primary producers use...Ch. 46 - Organisms at the lowest trophic level in a...Ch. 46 - Prob. 3SQCh. 46 - Prob. 4SQCh. 46 - Efficiency of energy transfers in aquatic...Ch. 46 - Prob. 6SQCh. 46 - Earths largest carbon reservoir is _______. a. the...Ch. 46 - Carbon is released into the atmosphere by _____ a....Ch. 46 - Prob. 1DAACh. 46 - Prob. 2DAA
Ch. 46 - Changes in the Air To assess the impact of human...Ch. 46 - Changes in the Air To assess the impact of human...Ch. 46 - Prob. 9SQCh. 46 - The _____ cycle is a sedimentary cycle. a....Ch. 46 - Earths largest phosphorus reservoir is _______. a....Ch. 46 - Prob. 12SQCh. 46 - Nitrogen fixation converts _______ to _______. a....Ch. 46 - Prob. 14SQCh. 46 - Prob. 15SQCh. 46 - Marguerite plants a vegetable garden in Maine....Ch. 46 - Where does your drinking water come from? An...Ch. 46 - Scientists study bubbles trapped in ancient...Ch. 46 - Nitrogen-fixing bacteria live throughout the...Ch. 46 - As noted in Section 46.7, mycorrhizal fungi help...
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