Campbell Biology (11th Edition)
Campbell Biology (11th Edition)
11th Edition
ISBN: 9780134093413
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece
Publisher: PEARSON
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Chapter 44, Problem 44.5CR

Why can only some patients with diabetes insipidus be treated effectively with ADH?

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Why can only some patients with diabetes insipidus be treated effectively with ADH?
Which of the following best describes the role of the hexosamine pathway in the pathogenesis of the chronic complications of diabetes mellitus? Question 79 options: a)  It involves irreversible binding of glucose to proteins, lipids and nucleic acids which damages components of the microcirculation leading to retinopathy, etc. b)  It promotes the O-linked glycosylation of proteins and transcription factors, resulting in altered gene expression contributing to insulin resistance & cardiovascular complications c)  It promotes the synthesis of DAG which increases pro-inflammatory gene expression and endothelial ET-1 production resulting in blood flow abnormalities d)  It leads to intracellular accumulation of osmotically active sorbitol and fructose which damages Schwann cells, erythrocytes and the lens of the eye
Diabetes insipidus has been identified in two males. One person did not have the condition until he had a stroke. The other had lived with the condition his whole life, and despite the existence of normal ADH receptors, it had never reacted to exogenous ADH. What might be the cause of the two men's diabetes insipidus? Provide your references.
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