Biology
12th Edition
ISBN: 9781260494570
Author: Raven, Peter
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 42, Problem 3S
Describe the steps required to produce an excitatory postsynaptic potential (EPSP). How would these differ at an inhibitory synapse?
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Let’s say the synapses of a neuron’s dendrites are filled with glutamate-gated channels which, when activated by glutamate, cause an excitatory postsynaptic potential (EPSP) in the neuron. In one instance, glutamate is released at all of the synapses simultaneously and this leads to an action potential in the neuron.
A) What type of summation of PSPs is this? Why?
B) List the sequence of steps that occur starting from binding of glutamate to the glutamate-gated channels at the synapses and ending with the membrane potential at the axon hillock returning to resting potential at the end of the action potential. (Include all the changes in voltage-gated channels underlying the action potential.)
What type of synaptic potential (if any; be sure to indicate if any modification is occurring as well) would occur if:
a.) An MAO inhibitor type of antidepressant is functioning at an active dopaminergic synapse that increases the rate of sodium flowing into the cell.
b.) Prozac is present at an active serotonin synapse where receptor activation increases the flow of potassium out of the cell.
Depression is a condition in which sufferers may feel low mood, lack of motivation and sleep. It is caused by a lack of serotonin in the synaptic cleft of neurone pathways. Serotonin is a neurotransmitter.
a) Describe how serotonin acts as a neurotransmitter. Using your understanding of synaptic transmission, explain how communication between neurones in serotonin pathways of the brain would be affected in someone with depression.
b) Doctors use tubocurarine drug as an anaesthetic as it temporarily paralyses muscles. It blocks receptors at neuromuscular junctions. Why does this lead to paralysis?
Chapter 42 Solutions
Biology
Ch. 42.1 - Differentiate between subdivisions of the...Ch. 42.1 - Prob. 2LOCh. 42.1 - Explain the roles of the different nervous system...Ch. 42.2 - Contrast the relative concentrations of important...Ch. 42.2 - Prob. 2LOCh. 42.2 - Prob. 3LOCh. 42.3 - Prob. 1LOCh. 42.3 - Prob. 2LOCh. 42.3 - Prob. 3LOCh. 42.4 - Prob. 1LO
Ch. 42.4 - Prob. 2LOCh. 42.4 - Prob. 3LOCh. 42.5 - Describe the organization of the peripheral...Ch. 42.5 - Prob. 2LOCh. 42.5 - Prob. 3LOCh. 42.5 - Prob. 4LOCh. 42 - Data analysis Draw the resulting potentials for...Ch. 42 - Prob. 2DACh. 42 - Which of the following best describes the...Ch. 42 - The ____ cannot be controlled by conscious...Ch. 42 - Prob. 3UCh. 42 - Inhibitory neurotransmitters a. hyperpolarize...Ch. 42 - White matter is ______, and gray matter is...Ch. 42 - During an action potential a. the rising phase is...Ch. 42 - Prob. 7UCh. 42 - Imagine that you are doing an experiment on the...Ch. 42 - The Na+/K+ ATPase pump is a. not required for...Ch. 42 - Prob. 3ACh. 42 - The following is a list of the components of a...Ch. 42 - Prob. 5ACh. 42 - As you sit quietly reading this sentence, the part...Ch. 42 - G proteincoupled receptors are involved in the...Ch. 42 - Tetraethylammonium (TEA) is a drug that blocks...Ch. 42 - Describe the status of the Na+ and K+ channels at...Ch. 42 - Describe the steps required to produce an...Ch. 42 - Prob. 4S
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- What is a synapse? Explain the difference between an excitatory and an inhibitory synapse.arrow_forwardWhy do neurotransmitters have to be removed from the synapse?arrow_forwardWhich of the following statements concerning synapses is FALSE? O A) Modulation of synaptic strength can be presynaptic of postsynaptic B) High frequency stimulation in the presynaptic neuron often leads to DECREASED neurotransmitter release O C) Modulation of synaptic strength can either be short term, lasting seconds, or long term, lasting as long as a lifetime. D) Agonists are drugs that mimic neurotransmitters and antagonists are drugs that block the action of neurotransmitters O E) Certain drugs prevent the reuptake of neurotransmitter from the synapsearrow_forward
- What is a post-synaptic potential and how is it caused? Describe the two types of post-synaptic potentials that can occur. Within this context, what does excitatory and inhibitory mean?arrow_forwardEvents at a chemical synapse usually involve opening both voltage-gated ion channels and chemically gated ion channels. Where are these ion channels located and what causes each to open?arrow_forwardWhen an impulse arrives at the synapse, the synaptic vesicles open and release neurotransmitters into the cleft within a thousandth of a second. Within another ten thousandth of a second, these molecules have diffused across the cleft and bound to receptor sites in the effector cell. In what two ways is transmission across a synapse terminated so that the neuron’s signal is concluded?arrow_forward
- What is an electrical synapse? Where can electrical synapses be found? Identify an advantage and a disadvantage of an electrical synapse compared to a chemical synapse.arrow_forwardAt a synapse, opening one sodium channel (for the normal duration before closing) causes a small depolarization. Opening a handful of sodium channels may cause a larger depolarization. Opening more channels may lead to an even larger depolarization, up to a point. Then the depolarization would be the same regardless of how many other sodium channels opened. Explain why the number of open channels increases the depolarization, and why it doesn’t matter beyond a certain point.arrow_forwardHow is the choice of neurochemical to be released at a synapse determined? A) We don't have enough information to draw conclusions about how this process occurs. B) The postsynaptic structure signals its "choice" to the presynaptic structure. C) The presynaptic structure begins to release its neurochemical onto postsynaptic structures, which adapt by producing the appropriate receptors. D) The "choice" is determined by the genes of both the pre- and postsynaptic cells.arrow_forward
- Propose a mechanism for the conversion of (C) to (D). (Note: It is not acceptable to propose a primary carbocation as an intermediate.)arrow_forwardDescribe how an action potential in a presynaptic neuron causes a) an excitatory postsynaptic potential; or b) an inhibitory postsynaptic potential in a postsynaptic neuronarrow_forwardGiven that graded potentials fade over distance, what type of synapse would be the most effective in starting or inhibiting an action potential?arrow_forward
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