INTEG. PRIN OF ZOO >LL< W/ CONNECT - FD
18th Edition
ISBN: 9781265230234
Author: HICKMAN
Publisher: MCG
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Textbook Question
Chapter 4, Problem 4RQ
What happens in the formation of an enzyme-substrate complex that favors the disruption of substrate bonds?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 4 Solutions
INTEG. PRIN OF ZOO >LL< W/ CONNECT - FD
Ch. 4 - State the first and second laws of thermodynamics....Ch. 4 - Explain what is meant by free energy in a system....Ch. 4 - Many biochemical reactions proceed slowly unless...Ch. 4 - What happens in the formation of an...Ch. 4 - Explain three ways that enzymes may be regulated...Ch. 4 - What is meant by a high-energy bond, and why might...Ch. 4 - Although ATP supplies energy to an endergonic...Ch. 4 - What is an oxidation-reduction reaction and why...Ch. 4 - Give an example of a final electron acceptor found...Ch. 4 - Why must glucose be primed with a high energy...
Ch. 4 - What happens to the electrons removed during the...Ch. 4 - Why is acetyl-CoA considered a strategic...Ch. 4 - Why are oxygen molecules important in oxidative...Ch. 4 - Explain how animals can generate ATP without...Ch. 4 - Why are animal fats sometimes called the king of...Ch. 4 - The breakdown of amino acids yields two products:...Ch. 4 - Explain the relationship between the amount of...Ch. 4 - Prob. 1FFT
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