INTEGRAT PRINC OF ZOO (LL W/ CONNECT)
INTEGRAT PRINC OF ZOO (LL W/ CONNECT)
18th Edition
ISBN: 9781264177875
Author: HICKMAN
Publisher: MCG
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Chapter 4, Problem 4RQ

What happens in the formation of an enzyme-substrate complex that favors the disruption of substrate bonds?

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"One of the symmetry breaking events in mouse gastrulation requires the amplification of Nodal on the side of the embryo opposite to the Anterior Visceral Endoderm (AVE). Describe one way by which Nodal gets amplified in this region." My understanding of this is that there are a few ways nodal is amplified though I'm not sure if this is specifically occurs on the opposite side of the AVE.  1. pronodal cleaved by protease -> active nodal 2. Nodal -> BMP4 -> Wnt-> nodal 3. Nodal-> Nodal, Fox1 binding site  4. BMP4 on outside-> nodal  Are all of these occuring opposite to AVE?
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