Microbiology: An Introduction (13th Edition)
13th Edition
ISBN: 9780134605180
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case, Derek Weber, Warner Bair
Publisher: PEARSON
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Textbook Question
Chapter 4, Problem 2MCQ
Which statement best describes what happens when a gram-positive bacterium is placed in distilled water and penicillin?
- a. No change will result; the solution is isotonic.
- b. Water will move into the cell.
- c. Water will move out of the cell.
- d. The cell will undergo osmotic lysis.
- e. Sucrose will move into the cell from an area of higher concentration to one of lower concentration.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 4 Solutions
Microbiology: An Introduction (13th Edition)
Ch. 4 - DRAW IT Diagram each of the following flagellar...Ch. 4 - Endospore formation is called (a) _____. It is...Ch. 4 - DRAW IT Draw the bacterial shapes listed in (a),...Ch. 4 - Match the structures in column A to their...Ch. 4 - Why is an endospore called a resting structure? Of...Ch. 4 - Compare and contrast the following a. simple...Ch. 4 - Prob. 7RCh. 4 - Starch is readily metabolized by many cells, but a...Ch. 4 - Match the characteristics of eukaryotic cells in...Ch. 4 - NAME IT What group of microbes is characterized by...
Ch. 4 - Which of the following is not a distinguishing...Ch. 4 - Which statement best describes what happens when a...Ch. 4 - Which statement best describes what happens when a...Ch. 4 - Which statement best describes what happens when a...Ch. 4 - Which of the following statements best describes...Ch. 4 - Which of the following is false about fimbriae? a....Ch. 4 - Which of the following pairs is mismatched? a....Ch. 4 - Which of the following pairs is mismatched? a....Ch. 4 - You have isolated a motile, gram-positive cell...Ch. 4 - The antibiotic amphothericin B disrupts plasma...Ch. 4 - How can prokaryotic cells be smaller than...Ch. 4 - The smallest eukaryotic cell is the motile alga...Ch. 4 - Two types of prokaryotic cells have been...Ch. 4 - In 1985, a 0.5-mm cell was discovered in...Ch. 4 - When E. coli cells are exposed to a hypertonic...Ch. 4 - Clostridium botulinum is a strict anaerobe; that...Ch. 4 - A South San Francisco child enjoyed bath time at...Ch. 4 - Live cultures of Bacillus thuringiensis (Dipel)...
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