Developmental Biology
11th Edition
ISBN: 9781605354705
Author: Scott F. Gilbert, Michael J. F. Barresi
Publisher: Sinauer Associates is an imprint of Oxford University Press
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Chapter 4, Problem 2DQ
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Based on new research iPSC-derived cardiovascular progenitor cells successfully seeded a decellularized mouse heart and differentiated into cardiomycocytes, smooth muscle, and endothelial cells. The reason behind ECM would have direct influence of differentiation of progenitor cells into these varied types.
Introduction:
Progenitor cells are distinguished from stem cells as they are early descendants of stem cells, which can differentiate to form one or more kinds of cells, and have limited ability to replicate in vivo or in vitro and their restricted differentiation capacity. Heart diseases are leading cause of death worldwide. Numerous research studies are focusing on heart tissue engineering by creating heart tissues.
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