What does the length of C-N bond in peptide linkage indicate about its strength and its bond order. Introduction: Peptide bond is defined as the type of chemical bond which is created between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

Question

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Answer 1

Question

Chapter 4, Problem 1P

(a)

Summary Introduction

To determine: What does the length of C-N bond in peptide linkage indicate about its strength and its bond order.

Introduction:

Peptide bond is defined as the type of chemical bond which is created between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(a)

Expert Solution

Explanation of Solution

Explanation:

Length of the body is defined as the distance present between two atoms that are bonded together by covalent bond. Order of the bond is defined as the number of chemical bonds that are found in between paired atoms. So, if a chemical bond has a higher bond order, then bonds between atoms are shorter and stronger. Bond length indicates bond order. The length of C-N bond is 1.32 Å. Bond length indicates that C-N bond is intermediate in strength and its bond order is present between single and double bond.

Conclusion

Conclusion:

Bond length depends on bond order and bond length. In C-N, it indicates that it lies between single and double bond and its strength is intermediate.

(b)

Summary Introduction

To determine: The observations of Pauling and Corey that tell about the ease of rotation about C-N peptide bond.

Introduction:

Peptide bond is defined as the type of chemical bond which is formed between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(b)

Expert Solution

Explanation of Solution

Explanation:

Pauling and Corey accomplished that the peptide C-N bond cannot rotate freely as they have partial double bond characters. The rotation occurs between N-Cα and Cα−C bonds.

Conclusion

Conclusion:

No free rotation in C-N bond is observed.

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Students have asked these similar questions

The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Answer 2

Question

Chapter 4, Problem 1P

(a)

Summary Introduction

To determine: What does the length of C-N bond in peptide linkage indicate about its strength and its bond order.

Introduction:

Peptide bond is defined as the type of chemical bond which is created between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(a)

Expert Solution

Explanation of Solution

Explanation:

Length of the body is defined as the distance present between two atoms that are bonded together by covalent bond. Order of the bond is defined as the number of chemical bonds that are found in between paired atoms. So, if a chemical bond has a higher bond order, then bonds between atoms are shorter and stronger. Bond length indicates bond order. The length of C-N bond is 1.32 Å. Bond length indicates that C-N bond is intermediate in strength and its bond order is present between single and double bond.

Conclusion

Conclusion:

Bond length depends on bond order and bond length. In C-N, it indicates that it lies between single and double bond and its strength is intermediate.

(b)

Summary Introduction

To determine: The observations of Pauling and Corey that tell about the ease of rotation about C-N peptide bond.

Introduction:

Peptide bond is defined as the type of chemical bond which is formed between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(b)

Expert Solution

Explanation of Solution

Explanation:

Pauling and Corey accomplished that the peptide C-N bond cannot rotate freely as they have partial double bond characters. The rotation occurs between N-Cα and Cα−C bonds.

Conclusion

Conclusion:

No free rotation in C-N bond is observed.

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Answer 3

Question

Chapter 4, Problem 1P

(a)

Summary Introduction

To determine: What does the length of C-N bond in peptide linkage indicate about its strength and its bond order.

Introduction:

Peptide bond is defined as the type of chemical bond which is created between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(a)

Expert Solution

Explanation of Solution

Explanation:

Length of the body is defined as the distance present between two atoms that are bonded together by covalent bond. Order of the bond is defined as the number of chemical bonds that are found in between paired atoms. So, if a chemical bond has a higher bond order, then bonds between atoms are shorter and stronger. Bond length indicates bond order. The length of C-N bond is 1.32 Å. Bond length indicates that C-N bond is intermediate in strength and its bond order is present between single and double bond.

Conclusion

Conclusion:

Bond length depends on bond order and bond length. In C-N, it indicates that it lies between single and double bond and its strength is intermediate.

(b)

Summary Introduction

To determine: The observations of Pauling and Corey that tell about the ease of rotation about C-N peptide bond.

Introduction:

Peptide bond is defined as the type of chemical bond which is formed between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(b)

Expert Solution

Explanation of Solution

Explanation:

Pauling and Corey accomplished that the peptide C-N bond cannot rotate freely as they have partial double bond characters. The rotation occurs between N-Cα and Cα−C bonds.

Conclusion

Conclusion:

No free rotation in C-N bond is observed.

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Answer 4

Question

Chapter 4, Problem 1P

(a)

Summary Introduction

To determine: What does the length of C-N bond in peptide linkage indicate about its strength and its bond order.

Introduction:

Peptide bond is defined as the type of chemical bond which is created between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(a)

Expert Solution

Explanation of Solution

Explanation:

Length of the body is defined as the distance present between two atoms that are bonded together by covalent bond. Order of the bond is defined as the number of chemical bonds that are found in between paired atoms. So, if a chemical bond has a higher bond order, then bonds between atoms are shorter and stronger. Bond length indicates bond order. The length of C-N bond is 1.32 Å. Bond length indicates that C-N bond is intermediate in strength and its bond order is present between single and double bond.

Conclusion

Conclusion:

Bond length depends on bond order and bond length. In C-N, it indicates that it lies between single and double bond and its strength is intermediate.

(b)

Summary Introduction

To determine: The observations of Pauling and Corey that tell about the ease of rotation about C-N peptide bond.

Introduction:

Peptide bond is defined as the type of chemical bond which is formed between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(b)

Expert Solution

Explanation of Solution

Explanation:

Pauling and Corey accomplished that the peptide C-N bond cannot rotate freely as they have partial double bond characters. The rotation occurs between N-Cα and Cα−C bonds.

Conclusion

Conclusion:

No free rotation in C-N bond is observed.

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Answer 5

Chapter 4, Problem 1P

(a)

Summary Introduction

To determine: What does the length of C-N bond in peptide linkage indicate about its strength and its bond order.

Introduction:

Peptide bond is defined as the type of chemical bond which is created between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(a)

Expert Solution

Explanation of Solution

Explanation:

Length of the body is defined as the distance present between two atoms that are bonded together by covalent bond. Order of the bond is defined as the number of chemical bonds that are found in between paired atoms. So, if a chemical bond has a higher bond order, then bonds between atoms are shorter and stronger. Bond length indicates bond order. The length of C-N bond is 1.32 Å. Bond length indicates that C-N bond is intermediate in strength and its bond order is present between single and double bond.

Conclusion

Conclusion:

Bond length depends on bond order and bond length. In C-N, it indicates that it lies between single and double bond and its strength is intermediate.

(b)

Summary Introduction

To determine: The observations of Pauling and Corey that tell about the ease of rotation about C-N peptide bond.

Introduction:

Peptide bond is defined as the type of chemical bond which is formed between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(b)

Expert Solution

Explanation of Solution

Explanation:

Pauling and Corey accomplished that the peptide C-N bond cannot rotate freely as they have partial double bond characters. The rotation occurs between N-Cα and Cα−C bonds.

Conclusion

Conclusion:

No free rotation in C-N bond is observed.

Answer 6

Chapter 4, Problem 1P

(a)

Summary Introduction

To determine: What does the length of C-N bond in peptide linkage indicate about its strength and its bond order.

Introduction:

Peptide bond is defined as the type of chemical bond which is created between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(a)

Expert Solution

Explanation of Solution

Explanation:

Length of the body is defined as the distance present between two atoms that are bonded together by covalent bond. Order of the bond is defined as the number of chemical bonds that are found in between paired atoms. So, if a chemical bond has a higher bond order, then bonds between atoms are shorter and stronger. Bond length indicates bond order. The length of C-N bond is 1.32 Å. Bond length indicates that C-N bond is intermediate in strength and its bond order is present between single and double bond.

Conclusion

Conclusion:

Bond length depends on bond order and bond length. In C-N, it indicates that it lies between single and double bond and its strength is intermediate.

Answer 7

Chapter 4, Problem 1P

(a)

Summary Introduction

To determine: What does the length of C-N bond in peptide linkage indicate about its strength and its bond order.

Introduction:

Peptide bond is defined as the type of chemical bond which is created between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

Answer 8

(a)

Expert Solution

Explanation of Solution

Explanation:

Length of the body is defined as the distance present between two atoms that are bonded together by covalent bond. Order of the bond is defined as the number of chemical bonds that are found in between paired atoms. So, if a chemical bond has a higher bond order, then bonds between atoms are shorter and stronger. Bond length indicates bond order. The length of C-N bond is 1.32 Å. Bond length indicates that C-N bond is intermediate in strength and its bond order is present between single and double bond.

Answer 9

(a)

Expert Solution

Answer 10

(a)

Expert Solution

Answer 11

Expert Solution

Answer 12

Conclusion

Conclusion:

Bond length depends on bond order and bond length. In C-N, it indicates that it lies between single and double bond and its strength is intermediate.

Answer 13

(b)

Summary Introduction

To determine: The observations of Pauling and Corey that tell about the ease of rotation about C-N peptide bond.

Introduction:

Peptide bond is defined as the type of chemical bond which is formed between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

(b)

Expert Solution

Explanation of Solution

Explanation:

Pauling and Corey accomplished that the peptide C-N bond cannot rotate freely as they have partial double bond characters. The rotation occurs between N-Cα and Cα−C bonds.

Conclusion

Conclusion:

No free rotation in C-N bond is observed.

Answer 14

(b)

Summary Introduction

To determine: The observations of Pauling and Corey that tell about the ease of rotation about C-N peptide bond.

Introduction:

Peptide bond is defined as the type of chemical bond which is formed between carboxyl group of one amino acid and amino group of another amino acid. It is a type of dehydration synthesis reaction which involves removal of water molecule.

Answer 15

(b)

Expert Solution

Explanation of Solution

Explanation:

Pauling and Corey accomplished that the peptide C-N bond cannot rotate freely as they have partial double bond characters. The rotation occurs between N-Cα and Cα−C bonds.