Biology: Concepts and Investigations
5th Edition
ISBN: 9781260542202
Author: Marielle Hoefnagels
Publisher: Mcgraw-hill Higher Education (us)
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Textbook Question
Chapter 37, Problem 3PIT
3. Add the following terms to this concept map: density-dependent, density-independent,
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 37 Solutions
Biology: Concepts and Investigations
Ch. 37.1 - Define population, community, and ecosystem.Ch. 37.1 - What is population density?Ch. 37.1 - Distinguish among the types of distribution in a...Ch. 37.1 - Prob. 4MCCh. 37.2 - Prob. 1MCCh. 37.2 - Prob. 2MCCh. 37.2 - Prob. 3MCCh. 37.2 - Prob. 4MCCh. 37.3 - Prob. 1MCCh. 37.3 - Prob. 2MC
Ch. 37.3 - Prob. 3MCCh. 37.3 - Prob. 4MCCh. 37.3 - Prob. 5MCCh. 37.4 - Prob. 1MCCh. 37.4 - Distinguish between opportunistic and equilibrium...Ch. 37.5 - Which parts of the world have the highest and...Ch. 37.5 - How does the demographic transition reflect...Ch. 37.5 - Prob. 3MCCh. 37.5 - What are some of the environmental consequences of...Ch. 37.6 - Prob. 1MCCh. 37.6 - Prob. 2MCCh. 37 - Population size increases when a. the sum of birth...Ch. 37 - Prob. 2MCQCh. 37 - Prob. 3MCQCh. 37 - Prob. 4MCQCh. 37 - Prob. 5MCQCh. 37 - Prob. 1WIOCh. 37 - Prob. 2WIOCh. 37 - Describe the difference between population density...Ch. 37 - Prob. 4WIOCh. 37 - Prob. 5WIOCh. 37 - Prob. 6WIOCh. 37 - Prob. 7WIOCh. 37 - Prob. 8WIOCh. 37 - Prob. 9WIOCh. 37 - Prob. 10WIOCh. 37 - Prob. 11WIOCh. 37 - A species with an opportunistic life history...Ch. 37 - 1. Review the Survey the Landscape figure in the...Ch. 37 - Prob. 2PITCh. 37 - 3. Add the following terms to this concept map:...
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