Chapter 37, Problem 25A

Summary Introduction

To write:

The sequence of events that occur to activate an antibody response to tetanus bacteria.

Introduction:

Immobilization of the antibody as the ligand will avoid binding avidity effects that result from the bivalency of the antibody.

Explanation of Solution

Tetanus toxic is an antigen known to induce strong T cell specific immune responses in humans after vaccination. Usually, the cloned deregulations of the antibody start response to tetanus- toxic after bone marrow transplantation. Immobilization of the antibody as the ligand will avoid binding avidity effects that result from the bivalency of the antibody. Many pathogenic microorganisms and toxins can be rendered harmless by the simple attachment of antibodies. Tetanus toxic is an antigen known to induce strong T cell specific immune responses in humans after vaccination.