INTEG. PRIN OF ZOO >LL< W/ CONNECT - FD
18th Edition
ISBN: 9781265230234
Author: HICKMAN
Publisher: MCG
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Textbook Question
Chapter 33, Problem 20RQ
Contrast the structure and functioning of the compound eye of arthropods with the camera-type eye of cephalopod molluscs and vertebrates.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 33 Solutions
INTEG. PRIN OF ZOO >LL< W/ CONNECT - FD
Ch. 33 - Define the following terms: neuron, axon,...Ch. 33 - Glial cells far outnumber neurons and contribute...Ch. 33 - The concentration of potassium ions inside a nerve...Ch. 33 - What ionic and electrical changes occur during...Ch. 33 - Explain different ways in which invertebrates and...Ch. 33 - Why is the sodium-potassium pump indirectly...Ch. 33 - Prob. 7RQCh. 33 - Prob. 8RQCh. 33 - Prob. 9RQCh. 33 - Prob. 10RQ
Ch. 33 - Prob. 11RQCh. 33 - Prob. 12RQCh. 33 - Prob. 13RQCh. 33 - Prob. 14RQCh. 33 - Chemoreception in vertebrates and insects is...Ch. 33 - What is the vomeronasal organ and what activity...Ch. 33 - Explain how ultrasonic detectors of certain...Ch. 33 - Outline the place theory of pitch discrimination...Ch. 33 - Explain how the semicircular canals of the ear are...Ch. 33 - Contrast the structure and functioning of the...Ch. 33 - Explain what happens when light strikes a...Ch. 33 - Prob. 22RQCh. 33 - Prob. 1FFT
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