Bundle: Introduction to General, Organic and Biochemistry, 11th + OWLv2, 4 terms (24 months) Printed Access Card
11th Edition
ISBN: 9781305705159
Author: Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher: Cengage Learning
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Question
Chapter 31, Problem 31.83P
Interpretation Introduction
Interpretation:
Determine the synthetic analog of the tumor cell marker, which can be used as an anticancer vaccine.
Concept Introduction:
Cancer is a disease characterized by abnormal cell division. It occurs when cells in a region of the body proliferate in an uncontrolled manner, the excess tissue that develops is called a tumor or neoplasm.
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need help please and thanks dont understand only need help with C-F
Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal…
Please correct answer and don't used hand raiting
need help please and thanks dont understand a-b
Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal energy
Divide the…
Chapter 31 Solutions
Bundle: Introduction to General, Organic and Biochemistry, 11th + OWLv2, 4 terms (24 months) Printed Access Card
Ch. 31 - Give two examples of external innate immunity in...Ch. 31 - Prob. 31.2PCh. 31 - Prob. 31.3PCh. 31 - Prob. 31.4PCh. 31 - Prob. 31.5PCh. 31 - Prob. 31.6PCh. 31 - Prob. 31.7PCh. 31 - 31-8 What are memory cells? What is their...Ch. 31 - Prob. 31.9PCh. 31 - Prob. 31.10P
Ch. 31 - Prob. 31.11PCh. 31 - Prob. 31.12PCh. 31 - Prob. 31.13PCh. 31 - Prob. 31.14PCh. 31 - Prob. 31.15PCh. 31 - Prob. 31.16PCh. 31 - When a foreign substance is injected in a rabbit,...Ch. 31 - Prob. 31.18PCh. 31 - (a) Which immunoglobulin has the highest...Ch. 31 - Chemical Connections 20D states that the antigen...Ch. 31 - Prob. 31.21PCh. 31 - Prob. 31.22PCh. 31 - Prob. 31.23PCh. 31 - Prob. 31.24PCh. 31 - Prob. 31.25PCh. 31 - Prob. 31.26PCh. 31 - What accounts for antibody diversity?Ch. 31 - Prob. 31.28PCh. 31 - Prob. 31.29PCh. 31 - Prob. 31.30PCh. 31 - Prob. 31.31PCh. 31 - Prob. 31.32PCh. 31 - Prob. 31.33PCh. 31 - Prob. 31.34PCh. 31 - Prob. 31.35PCh. 31 - Prob. 31.36PCh. 31 - Prob. 31.37PCh. 31 - Prob. 31.38PCh. 31 - Prob. 31.39PCh. 31 - Prob. 31.40PCh. 31 - Prob. 31.41PCh. 31 - Prob. 31.42PCh. 31 - Prob. 31.43PCh. 31 - Prob. 31.44PCh. 31 - Prob. 31.45PCh. 31 - Prob. 31.46PCh. 31 - Prob. 31.47PCh. 31 - Prob. 31.48PCh. 31 - Prob. 31.49PCh. 31 - Prob. 31.50PCh. 31 - Prob. 31.51PCh. 31 - Prob. 31.52PCh. 31 - Prob. 31.53PCh. 31 - Prob. 31.54PCh. 31 - Prob. 31.55PCh. 31 - Prob. 31.56PCh. 31 - Prob. 31.57PCh. 31 - Prob. 31.58PCh. 31 - Prob. 31.59PCh. 31 - Prob. 31.60PCh. 31 - Prob. 31.61PCh. 31 - Prob. 31.62PCh. 31 - Prob. 31.63PCh. 31 - Prob. 31.64PCh. 31 - Prob. 31.65PCh. 31 - Prob. 31.66PCh. 31 - Prob. 31.67PCh. 31 - Prob. 31.68PCh. 31 - Prob. 31.69PCh. 31 - Prob. 31.70PCh. 31 - Prob. 31.71PCh. 31 - Prob. 31.72PCh. 31 - Prob. 31.73PCh. 31 - Prob. 31.74PCh. 31 - Prob. 31.75PCh. 31 - Prob. 31.76PCh. 31 - Prob. 31.77PCh. 31 - Prob. 31.78PCh. 31 - Prob. 31.79PCh. 31 - Prob. 31.80PCh. 31 - Prob. 31.81PCh. 31 - Prob. 31.82PCh. 31 - Prob. 31.83PCh. 31 - Prob. 31.84PCh. 31 - Prob. 31.85PCh. 31 - Prob. 31.86P
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SAR of Anticancer(Antineoplastic) Drug/ Alkylating agents/ Nitrogen Mustard; Author: Pharmacy Lectures;https://www.youtube.com/watch?v=zrzyK3LhUXs;License: Standard YouTube License, CC-BY