HUMAN BIOLOGY:CONC.+CURRENT..(LOOSE)
7th Edition
ISBN: 9780321862525
Author: Johnson
Publisher: PEARSON
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Chapter 3, Problem 7TY
Summary Introduction
Introduction:
Lymphocytes are cells, which are involved in the body’s defense mechanism. They produce proteins known as antibodies that protect the body against pathogens. The process that these cells utilize to produce these antibodies includes a number of cell organelles and components including ribosomes, plasma membrane, vesicles, endoplasmic reticulum, and Golgi apparatus.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 3 Solutions
HUMAN BIOLOGY:CONC.+CURRENT..(LOOSE)
Ch. 3 -
1. What is your opinion on this controversy? What...Ch. 3 - Prob. 2QCCh. 3 - Prob. 1CRCh. 3 - Prob. 2CRCh. 3 - Describe how phospholipids are oriented in the...Ch. 3 - Define passive transport and name the three...Ch. 3 - Compare and contrast endocytosis and exocytosis.Ch. 3 - Describe the activity of the sodium-potassium pump...Ch. 3 - Prob. 7CRCh. 3 - Prob. 8CR
Ch. 3 -
9. What are the four stages of ATP production...Ch. 3 -
10. Describe what happens to a cell’s ability to...Ch. 3 -
1. Which of the following adaptations would...Ch. 3 - Which of the following would be most likely to...Ch. 3 - Prob. 3TYCh. 3 - Red blood cells placed in distilled water will: a....Ch. 3 - Which organelles are most active during vigorous...Ch. 3 - Phagocytic white blood cells engulf and digest...Ch. 3 - Prob. 7TYCh. 3 -
8. Which organelles would be active in liver...Ch. 3 - Prob. 9TYCh. 3 -
10. Which of the following is/are the most...Ch. 3 - Prob. 11TYCh. 3 - Prob. 12TYCh. 3 -
13. In which stage of cell respiration does...Ch. 3 - Which of the following is/are recycled during...Ch. 3 - Most of the ATP produced during cell respiration...Ch. 3 - Imagine that you are shown two cells under the...Ch. 3 - The sodium-potassium pump is a large protein...Ch. 3 - Mitochondria resemble a bacterial cell in a number...Ch. 3 - Prob. 4AWKCh. 3 - Recently, a young man from Derby in the United...Ch. 3 - You have been selected to serve on a jury for a...
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