BELK SCIENCE F/LIFE-MASTRG. BIOL.AC+EBK
6th Edition
ISBN: 9781323907634
Author: BELK
Publisher: PEARSON
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Chapter 3, Problem 1GFO
Select one supplement you have wondered about and spend a few minutes doing some web- based research on whether the claims made on its label are backed up by scientific evidence
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Chapter 3 Solutions
BELK SCIENCE F/LIFE-MASTRG. BIOL.AC+EBK
Ch. 3 - Prob. 1LTBCh. 3 - Add labels to the figure that follows, which...Ch. 3 - Prob. 3LTBCh. 3 - Which of the following is not a function of water?...Ch. 3 - Prob. 5LTBCh. 3 - Prob. 6LTBCh. 3 - Prob. 7LTBCh. 3 - Prob. 8LTBCh. 3 - Which of the following forms of membrane transport...Ch. 3 - Prob. 10LTB
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