To provide: A regulatory strategy for the given metabolic pathway for synthesis of AMP and GMP from R5P using principles of feedback inhibition that ensures an adequate supply of both AMP and GMP and minimized the buildup of the intermediates ( A-I ) when supplies of AMP and GMP are adequate. Concept introduction: Purine nucleotides Adenosine monophosphate (AMP) and Guanosine (GMP) are required for DNA replication. The purines are produced from Ribose 5- phosphate (R5P). Negative feedback loop is where the change in the internal environment is reversed or reduced. Positive feedback loop is where the change in the internal environment in amplified or increased.

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*Example 2: Tracing the path of an autosomal dominant trait Trait: Neurofibromatosis Forms of the trait: The dominant form is neurofibromatosis, caused by the production of an abnormal form of the protein neurofibromin. Affected individuals show spots of abnormal skin pigmentation and non-cancerous tumors that can interfere with the nervous system and cause blindness. Some tumors can convert to a cancerous form. i The recessive form is a normal protein - in other words, no neurofibromatosis.moovi A typical pedigree for a family that carries neurofibromatosis is shown below. Note that carriers are not indicated with half-colored shapes in this chart. Use the letter "N" to indicate the dominant neurofibromatosis allele, and the letter "n" for the normal allele. Nn nn nn 2 nn Nn A 3 N-

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Chapter 3, Problem 18P

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To provide: A regulatory strategy for the given metabolic pathway for synthesis of AMP and GMP from R5P using principles of feedback inhibition that ensures an adequate supply of both AMP and GMP and minimized the buildup of the intermediates (A-I) when supplies of AMP and GMP are adequate.

Concept introduction: Purine nucleotides Adenosine monophosphate (AMP) and Guanosine (GMP) are required for DNA replication. The purines are produced from Ribose 5- phosphate (R5P). Negative feedback loop is where the change in the internal environment is reversed or reduced. Positive feedback loop is where the change in the internal environment in amplified or increased.

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*Example 2: Tracing the path of an autosomal dominant trait Trait: Neurofibromatosis Forms of the trait: The dominant form is neurofibromatosis, caused by the production of an abnormal form of the protein neurofibromin. Affected individuals show spots of abnormal skin pigmentation and non-cancerous tumors that can interfere with the nervous system and cause blindness. Some tumors can convert to a cancerous form. i The recessive form is a normal protein - in other words, no neurofibromatosis.moovi A typical pedigree for a family that carries neurofibromatosis is shown below. Note that carriers are not indicated with half-colored shapes in this chart. Use the letter "N" to indicate the dominant neurofibromatosis allele, and the letter "n" for the normal allele. Nn nn nn 2 nn Nn A 3 N-

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