Chapter 29, Problem 29.69P

Interpretation Introduction

Interpretation:

The reaction conditions that would bind an Fmoc-protected amino acid to a Wang resin are to be proposed. The reaction condition that could be used to remove the polypeptide from the resin after the completion of synthesis is to be predicted.

Concept introduction:

Peptide linkage is formed between the amino group of one amino acid and the carboxyl group of other amino acid with the loss of water molecule. Amino acids are naturally occurring compounds in which the amino group is present on the alpha carbon of carboxyl group. The full form of Fmoc $-\text{Cl}$ is fluorenylmethyloxycarbonyl chloride. It introduces Fmoc group which protects the amine group in organic synthesis.