CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
8th Edition
ISBN: 9781259880193
Author: SALADIN
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 28.4, Problem 14BYGO
Summary Introduction
Introduction:
The female sexual response and the physical changes that happen at the time of coitus can be seen in four stages: excitement, plateau, orgasm, and resolution. The vascular regulation and neurological regulation of female sexual response are fundamentally are similar to those observed in males.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 28 Solutions
CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
Ch. 28.1 - Prob. 1BYGOCh. 28.1 - How is the structure of the uterine tube mucosa...Ch. 28.1 - Prob. 3BYGOCh. 28.1 - Prob. 4BYGOCh. 28.1 - Prob. 1AYLOCh. 28.1 - What mature female structures arise from the...Ch. 28.1 - Prob. 3AYLOCh. 28.1 - General structure of ovarian follicles; their...Ch. 28.1 - Prob. 5AYLOCh. 28.1 - Prob. 6AYLO
Ch. 28.1 - Prob. 7AYLOCh. 28.1 - The tilt of the vagina and its relationship to...Ch. 28.1 - Prob. 9AYLOCh. 28.1 - Prob. 10AYLOCh. 28.1 - The prevalence of breast cancer; its diagnostic...Ch. 28.2 - Prob. 5BYGOCh. 28.2 - Prob. 6BYGOCh. 28.2 - Prob. 7BYGOCh. 28.2 - Prob. 1AYLOCh. 28.2 - Prob. 2AYLOCh. 28.2 - Thelarche, pubarche, and menarche as signs of...Ch. 28.2 - Prob. 4AYLOCh. 28.2 - Prob. 5AYLOCh. 28.2 - Ovarian and hormonal changes that bring on female...Ch. 28.2 - Prob. 7AYLOCh. 28.3 - Prob. 8BYGOCh. 28.3 - Prob. 9BYGOCh. 28.3 - Prob. 10BYGOCh. 28.3 - Describe what happens in the uterus during the...Ch. 28.3 - Describe the effects of FSH and LH on the ovary.Ch. 28.3 - Prob. 13BYGOCh. 28.3 - Prob. 1AYLOCh. 28.3 - Prob. 2AYLOCh. 28.3 - Prob. 3AYLOCh. 28.3 - Ways in winch meiosis in the female differs from...Ch. 28.3 - How far meiosis has progressed by the time the egg...Ch. 28.3 - Prob. 6AYLOCh. 28.3 - Prob. 7AYLOCh. 28.3 - Prob. 8AYLOCh. 28.3 - Prob. 9AYLOCh. 28.3 - Prob. 10AYLOCh. 28.3 - Prob. 11AYLOCh. 28.3 - Production, structure, function, and eventual...Ch. 28.3 - Four phases of the menstrual cycle; what happens...Ch. 28.4 - Prob. 14BYGOCh. 28.4 - Prob. 15BYGOCh. 28.4 - Prob. 16BYGOCh. 28.4 - Prob. 1AYLOCh. 28.4 - Physiological responses of orgasm and resolution...Ch. 28.5 - List the roles of HCG, estrogen, progesterone, and...Ch. 28.5 - Prob. 18BYGOCh. 28.5 - Prob. 19BYGOCh. 28.5 - Prob. 20BYGOCh. 28.5 - Prob. 21BYGOCh. 28.5 - Prob. 22BYGOCh. 28.5 - Prob. 1AYLOCh. 28.5 - Prob. 2AYLOCh. 28.5 - Prob. 3AYLOCh. 28.5 - Prob. 4AYLOCh. 28.5 - Prob. 5AYLOCh. 28.5 - Causes of morning sickness, constipation, and...Ch. 28.5 - Prob. 7AYLOCh. 28.5 - Prob. 8AYLOCh. 28.6 - Prob. 23BYGOCh. 28.6 - Prob. 24BYGOCh. 28.6 - Prob. 25BYGOCh. 28.6 - Prob. 26BYGOCh. 28.6 - Prob. 27BYGO
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