To assign R or S configuration to each chirality center in prostaglandin E2, the most abundant and biologically potent of mammalian prostaglandins. Concept introduction: The prostaglandins are a group of C 20 lipids that contain a five-membered ring with two long side chains. They have wide range of biological functions like lowering blood pressure, affect blood platelet aggregation during clotting, lower gastric secretions, control inflammation, affect kidney function, affect reproductive systems, and stimulate uterine contractions during childbirth. To determine: To assign R or S configuration to each chirality center in prostaglandin E2.

Question

Normalized Intensity (a. u.) 0.5 1.0 A 3D-printed GC column (shown below) was created for use with "micro" gas chromatography applications. To prove its utility, it was used to separate a mixture of alkanes (C9-C18, C22, C24). For the separation shown below, the column temperature was ramped from 40 °C to 250 °C at a rate of 30 °C per minute. (a) 9 10 = 1 mm 12 13 15 22 0.0 0 100 200 300 400 Time (sec) a) What detector would you use for this analysis? Justify your selection. b) Explain how the chromatogram would change if the separation was run isothermally. c) Explain how the chromatogram would change if the temperature ramp were increased to 50 °C per minute.

Answer 1

Question

Chapter 27.4, Problem 5P

Interpretation Introduction

Interpretation:

To assign R or S configuration to each chirality center in prostaglandin E2, the most abundant and biologically potent of mammalian prostaglandins.

Concept introduction:

The prostaglandins are a group of C₂₀ lipids that contain a five-membered ring with two long side chains. They have wide range of biological functions like lowering blood pressure, affect blood platelet aggregation during clotting, lower gastric secretions, control inflammation, affect kidney function, affect reproductive systems, and stimulate uterine contractions during childbirth.

To determine:

To assign R or S configuration to each chirality center in prostaglandin E2.

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