
Concept explainers
Interpretation:
The N-terminal residue on a peptide that gives the PTH derivative shown upon Edmund degradation is to be stated.
Concept introduction:
Edmund degradation involves the treatment of a peptide with phenylisothiocyanate(PITC) followed by treatment with trifluoroacetic acid. In the first step PITC attacks the NH2 group of the N-terminal acid. In the second step the N-terminal acid residue splits from the peptide chain to yield an anilinothiazolinone(ATZ) derivative along with chain shortened peptide chain. In the third step the acid converts ATZ into a phenylthiohydantoin (PTH).
To give:
The N-terminal residue on a peptide that gives the PTH derivative shown upon Edmund degradation.

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Chapter 26 Solutions
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