During peptide synthesis fluorenylmethyloxycarbonyl amide (Fmoc) derivatives are used to protect the amine group and after formation of the peptide they are removed using base treatment. Concept introduction: The Fmoc derivative is used to protect the amine group of amino acid during peptide formation. But it is important to remove the Fmoc derivative after peptide synthesis. This process is carried out using treatment with an aqueous base. Often amine base piperidine is used. To determine: The mechanism of removal of Fmoc derivative from amine group using the amine base piperidine.

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Answer 1

Question

Chapter 26.SE, Problem 26MP

Interpretation Introduction

Interpretation:

During peptide synthesis fluorenylmethyloxycarbonyl amide (Fmoc) derivatives are used to protect the amine group and after formation of the peptide they are removed using base treatment.

Concept introduction:

The Fmoc derivative is used to protect the amine group of amino acid during peptide formation. But it is important to remove the Fmoc derivative after peptide synthesis. This process is carried out using treatment with an aqueous base. Often amine base piperidine is used.

To determine:

The mechanism of removal of Fmoc derivative from amine group using the amine base piperidine.

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Answer 2

Question

Chapter 26.SE, Problem 26MP

Interpretation Introduction

Interpretation:

During peptide synthesis fluorenylmethyloxycarbonyl amide (Fmoc) derivatives are used to protect the amine group and after formation of the peptide they are removed using base treatment.

Concept introduction:

The Fmoc derivative is used to protect the amine group of amino acid during peptide formation. But it is important to remove the Fmoc derivative after peptide synthesis. This process is carried out using treatment with an aqueous base. Often amine base piperidine is used.

To determine:

The mechanism of removal of Fmoc derivative from amine group using the amine base piperidine.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 26.SE, Problem 26MP

Interpretation Introduction

Interpretation:

During peptide synthesis fluorenylmethyloxycarbonyl amide (Fmoc) derivatives are used to protect the amine group and after formation of the peptide they are removed using base treatment.

Concept introduction:

The Fmoc derivative is used to protect the amine group of amino acid during peptide formation. But it is important to remove the Fmoc derivative after peptide synthesis. This process is carried out using treatment with an aqueous base. Often amine base piperidine is used.

To determine:

The mechanism of removal of Fmoc derivative from amine group using the amine base piperidine.

Expert Solution & Answer

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Answer 4

Question

Chapter 26.SE, Problem 26MP

Interpretation Introduction

Interpretation:

During peptide synthesis fluorenylmethyloxycarbonyl amide (Fmoc) derivatives are used to protect the amine group and after formation of the peptide they are removed using base treatment.

Concept introduction:

The Fmoc derivative is used to protect the amine group of amino acid during peptide formation. But it is important to remove the Fmoc derivative after peptide synthesis. This process is carried out using treatment with an aqueous base. Often amine base piperidine is used.

To determine:

The mechanism of removal of Fmoc derivative from amine group using the amine base piperidine.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 5

Chapter 26.SE, Problem 26MP

Interpretation Introduction

Interpretation:

During peptide synthesis fluorenylmethyloxycarbonyl amide (Fmoc) derivatives are used to protect the amine group and after formation of the peptide they are removed using base treatment.

Concept introduction:

The Fmoc derivative is used to protect the amine group of amino acid during peptide formation. But it is important to remove the Fmoc derivative after peptide synthesis. This process is carried out using treatment with an aqueous base. Often amine base piperidine is used.

To determine:

The mechanism of removal of Fmoc derivative from amine group using the amine base piperidine.

Answer 6

Chapter 26.SE, Problem 26MP

Interpretation Introduction

Interpretation:

During peptide synthesis fluorenylmethyloxycarbonyl amide (Fmoc) derivatives are used to protect the amine group and after formation of the peptide they are removed using base treatment.

Concept introduction:

The Fmoc derivative is used to protect the amine group of amino acid during peptide formation. But it is important to remove the Fmoc derivative after peptide synthesis. This process is carried out using treatment with an aqueous base. Often amine base piperidine is used.

To determine:

The mechanism of removal of Fmoc derivative from amine group using the amine base piperidine.

Answer 7

Chapter 26.SE, Problem 26MP

Interpretation Introduction

Interpretation:

During peptide synthesis fluorenylmethyloxycarbonyl amide (Fmoc) derivatives are used to protect the amine group and after formation of the peptide they are removed using base treatment.

Concept introduction:

The Fmoc derivative is used to protect the amine group of amino acid during peptide formation. But it is important to remove the Fmoc derivative after peptide synthesis. This process is carried out using treatment with an aqueous base. Often amine base piperidine is used.

To determine:

The mechanism of removal of Fmoc derivative from amine group using the amine base piperidine.

Answer 8

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Answer 9

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Answer 10

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Answer 11

Ch. 26.1 - How many of the -amino acids shown in Table 26-1...Ch. 26.1 - Prob. 2P Ch. 26.1 - Prob. 3P Ch. 26.2 - Hemoglobin has pI=6.8. Does hemoglobin have a net...Ch. 26.3 - Show how you could prepare the following -amino...Ch. 26.3 - What alkyl halides would you use to prepare the...Ch. 26.3 - Prob. 7P Ch. 26.4 - There are six isomeric tripeptides that contain...Ch. 26.4 - Draw the structure of M-P-V-G, and indicate its...Ch. 26.5 - Prob. 10P

Solution Summary: The author explains how the Fmoc derivative is used to protect the amine group of amino acid during peptide formation.

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Chapter 26 Solutions