(a) Interpretation: The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined. The reason for the surprising results should be determined. Concept introduction: Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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Answer 1

Question

Chapter 26, Problem 39P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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Two tetrapeptides were isolated from a possum's sweat glands. These peptides were sequenced using Edman degradation and the following 2 sequences were obtained: Gly-Asp-Ala-Leu Gly-Asp-Asp-Leu What is the structure of the PTH derivative produced during the last round of amino acid sequencing?

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Answer 2

Question

Chapter 26, Problem 39P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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Answer 3

Question

Chapter 26, Problem 39P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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Answer 4

Question

Chapter 26, Problem 39P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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Answer 5

Chapter 26, Problem 39P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 6

Chapter 26, Problem 39P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 7

Chapter 26, Problem 39P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 8

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 9

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 10

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 11

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 12

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 13

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 14

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Answer 17

Ch. 26 - Prob. 1P Ch. 26 - Prob. 2P Ch. 26 - Prob. 3P Ch. 26 - Prob. 4P Ch. 26 - Prob. 5P Ch. 26 - Prob. 6P Ch. 26 - Prob. 7P Ch. 26 - Prob. 8P Ch. 26 - Prob. 9P Ch. 26 - Prob. 10P

Solution Summary: The author explains that Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase).

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