Concept explainers
(a)
Interpretation:
The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.
The reason for the surprising results should be determined.
Concept introduction:
Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.
(b)
Interpretation:
Two possible explanations for the figure B should be determined.
The reason to ensure that the extracts have the same number of cells should be determined.
The purpose for including the western blot for actin should be determined.
Concept introduction:
Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.
(c)
Interpretation:
If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.
Concept introduction:
Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.
(d)
Interpretation:
The nature of defect in GD enzyme should be determined.
The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.
Concept introduction:
Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Want to see the full answer?
Check out a sample textbook solution
Chapter 26 Solutions
BIOCHEMISTRY
- Draw the product of this reaction. Ignore inorganic byproducts. H H ⚫OH HO- -H H- -OH H- -OH CH2OH Ag*, NH4OH, H2O Draw Fischer Projectionarrow_forwardDraw the product of this reaction. Ignore inorganic byproducts. H₂O -OH H ⚫OH HO H HO- CH2OH Cu2+ Draw Fischer Projectionarrow_forwardDraw the product of this reaction. Ignore inorganic byproducts. H、 H -OH H ⚫OH H -OH CH2OH Fehlings' solution ⑤ Draw Fischer Projectionarrow_forward
- Draw the product of this reaction. Ignore inorganic byproducts. HO C=0 H ⚫OH H ⚫OH HO- H HO H CH2OH Tollens' solution Draw Fischer Projectionarrow_forwardDraw the product of this reaction. Ignore inorganic byproducts. H-C=O HO H HO H H- ⚫OH HO H CH2OH HNO3, H2O Draw Fischer Projectionarrow_forwardDraw the product of this reaction. Ignore inorganic byproducts. HO HO- HO H HO ∙H HO CH2OH NaBH4, CH3OH Draw Fischer Projectionarrow_forward
- Draw the product of this reaction. Ignore inorganic byproducts. Но сво HO H HO H H OH H -OH CH2OH H2 Pd Draw Fischer Projectionarrow_forwardDraw the Haworth projection for Gulose-ẞ-1,6-sorbose and answer the following questions. (Gulose will be in the pyranose form and Sorbose will be in the furanose form) a. Label the reducing and nonreducing ends of the disaccharide b. Label the glycosidic bond c. Circle the anomeric carbons and label them as hemiacetals or acetals. d. Can this disaccharide undergo mutarotation?arrow_forwardDraw the product of the reaction below. Ignore inorganic byproducts. H OH HO HO HO ·H H OH H OH excess CH3CH2I KOHarrow_forward
- Draw the Haworth structures for the following: a. α-D-Gulopyranose b. ẞ-D-Sorbofuranose c. The two possible isomers of a-D-altrose (furanose and pyranose forms)arrow_forwardDraw the product of this reaction. Ignore inorganic byproducts. HO H ⚫OH HO- ∙H H- -OH H ⚫OH CH2OH HNO3, H2Oarrow_forwardDraw the product of the reaction below. Ignore inorganic byproducts. HO CH2OH OH OH OH excess CHзI Ag2Oarrow_forward
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
- Anatomy & PhysiologyBiologyISBN:9781938168130Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark WomblePublisher:OpenStax CollegeHuman Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage LearningBiology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage Learning




