BIOCHEMISTRY
BIOCHEMISTRY
8th Edition
ISBN: 9781319296186
Author: BERG
Publisher: MAC HIGHER
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Chapter 26, Problem 34P
Interpretation Introduction

Interpretation:

The 3-hydroxy-3-methylglutaryl-CoA (HMG CoA) takes part in the production of cholesterol. Another pathway that involves the HMG CoA should be determined. Also, the factor that influences the pathway should be determined.

Concept introduction:

Cholesterol is a type of steroid. Cholesterol production starts with the help of Acetyl CoA (substrate as fatty acid synthesis). The steps for the biosynthesis of cholesterol are the formation of isoprene units, squalene formation and the cyclization of squalene.

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Two tetrapeptides were isolated from a possum's sweat glands. These peptides were sequenced using Edman degradation and the following 2 sequences were obtained: Gly-Asp-Ala-Leu  Gly-Asp-Asp-Leu  Can you please help show the titration curve for both of these peptides and calculate the PI?
Two tetrapeptides were isolated from a possum's sweat glands. These peptides were sequenced using Edman degradation and the following 2 sequences were obtained: Gly-Asp-Ala-Leu  Gly-Asp-Asp-Leu  What is the structure of the PTH derivative produced during the last round of amino acid sequencing?
What is the primary sequence of this undecapeptide? Also,   if x-ray crystallography shows a highly stable hairpin turn within the polypeptide, what about the primary sequence explains this structural feature?
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