Concept explainers
Biaryls, compounds containing two
a. b. c.
(a)
Interpretation: The synthesis of given biaryl compound using benzene as the starting material and any required organic or inorganic reagents is to be stated, and if more than one route is possible, then both routes are to be drawn.
Concept introduction: The treatment of an organic halide
Answer to Problem 26.45P
The synthesis of given biaryl compound (two routes) using benzene as the starting material and any required organic or inorganic reagents are shown below.
Explanation of Solution
The treatment of an organic halide
The retrosynthetic analysis of the given compound is,
Figure 1
The above analysis shows that there are two possible routes to synthesize the given compound.
Route 1:
The Route 1 involves formation of desired biaryl in nine steps. The first step is Friedel-Crafts alkylation of benzene with
Figure 2
Route 2:
The Route 2 involves
Figure 3
The synthesis of given biaryl compound (two routes) using benzene as the starting material and any required organic or inorganic reagents are shown in Figure 2, and Figure 3.
(b)
Interpretation: The synthesis of given biaryl compound using benzene as the starting material and any required organic or inorganic reagents is to be stated, and if more than one route is possible, then both routes are to be drawn.
Concept introduction: The treatment of an organic halide
Answer to Problem 26.45P
The synthesis of given biaryl compound (two routes) using benzene as the starting material and any required organic or inorganic reagents are shown below.
Explanation of Solution
The treatment of an organic halide
The retrosynthetic analysis of the given compound is,
Figure 4
The above analysis shows that there are two possible routes to synthesize the given compound.
Route 1:
The Route 1 involves eight steps. The first step is bromination of benzene in the presence of
Figure 5
Route 2:
The Route 2 involves
Figure 6
The synthesis of given biaryl compound (two routes) using benzene as the starting material and any required organic or inorganic reagents are shown in Figure 5, and Figure 6.
(c)
Interpretation: The synthesis of given biaryl compound using benzene as the starting material and any required organic or inorganic reagents is to be stated, and if more than one route is possible, then both routes are to be drawn.
Concept introduction: The treatment of an organic halide
Answer to Problem 26.45P
The synthesis of given biaryl compound (two routes) using benzene as the starting material and any required organic or inorganic reagents are shown below.
Explanation of Solution
The treatment of an organic halide
The retrosynthetic analysis of the given compound is,
Figure 7
The above analysis shows that there are two possible routes to synthesize the given compound.
Route 1:
The Route 1 involves eight steps. The first step is bromination of benzene in the presence of
Figure 8
Route 2:
The Route 2 involves
Figure 9
The synthesis of given biaryl compound (two routes) using benzene as the starting material and any required organic or inorganic reagents are shown in Figure 8, and Figure 9.
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Chapter 26 Solutions
Organic Chemistry
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