Organic Chemistry (8th Edition)
Organic Chemistry (8th Edition)
8th Edition
ISBN: 9780134042282
Author: Paula Yurkanis Bruice
Publisher: PEARSON
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Chapter 26, Problem 18P

What nonapeptide is coded for by the following fragment of mRNA?

5’—AAA—GUU—GGC—UAC—CCC—GGA—AUG—GUG—GUC—3’

Expert Solution & Answer
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Interpretation Introduction

Interpretation:

Nonapeptide which is coded for by the given strand of mRNA.

Concept introduction:

RNA is the abbreviation term of “Ribonucleic Acid”.  It is a complex molecule found in all living things.

RNA helps to make proteins.

Important RNAs such as messenger RNA (mRNA), rRNA (ribosomal RNA) and tRNA (transfer RNA) and their functions are mentioned below,

RNAFunctionmRNAinstructionstoproteinrRNApartoftheribosomestRNAcarriersthatmatchaminoacidstocodonsduringtranslation

Codons are the sequence of three bases in mRNA that specifies the amino acid to be incorporated into a protein.

Some amino acids and their corresponding mRNA codons are listed below,

Aminoacid*mRNAcodonsAla_nineGCU,GCC,GCA,GCGAsp_aragineGAU,GACVal_ineGUU,GUC,GUA,GUGHis_tidineCAU,CACMet_hionineAUGCys_teineUGU,UGCPro_lineCCU,CCC,CCA,CCGLys_ineAAA,AAGGly_cineGGU,GGC,GGA,GGGTyr_osineUAU,UAC*Thethreelettercodeforeachaminoacidisunderlined.

Anticodons are the matching sequence on the tRNA to the codon on the mRNA.

A base is nitrogen containing heterocyclic compound which is found in DNA and RNA.

There are mainly four nitrogen bases in RNA.

  1. (1) Adenine
  2. (2) Guanine
  3. (3) Cytosine
  4. (4) Uracil

In RNA, Adenine always makes a double bond with uracil (A=U) and cytosine always makes triple bond with guanine (GC)

Answer to Problem 18P

Nonapeptide coded for given fragment is,

LysValGlyTyrProGlyMetValVal

Explanation of Solution

Some amino acids and their corresponding mRNA codons are listed below,

Aminoacid*mRNAcodonsAla_nineGCU,GCC,GCA,GCGAsp_aragineGAU,GACVal_ineGUU,GUC,GUA,GUGHis_tidineCAU,CACMet_hionineAUGCys_teineUGU,UGCPro_lineCCU,CCC,CCA,CCGLys_ineAAA,AAGGly_cineGGU,GGC,GGA,GGGTyr_osineUAU,UAC*Thethreelettercodeforeachaminoacidisunderlined.

Given,

Strand of mRNA is,

5'-AAA-GUU-GGC-UAC-CCC-GGA-AUG-GUG-GUC-3'

Using the above table, the given mRNA fragment of nonapeptide can be coded as,

LysValGlyTyrProGlyMetValVal

Conclusion

The nonapeptide is coded for given strand of mRNA was given.

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Organic Chemistry (8th Edition)

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Nucleic acids - DNA and RNA structure; Author: MEDSimplified;https://www.youtube.com/watch?v=0lZRAShqft0;License: Standard YouTube License, CC-BY