(a)
Interpretation: The starting materials needed to prepare the given drug using reductive amination are to be determined.
Concept introduction: The conversion of
(b)
Interpretation: The starting materials needed to prepare the given drug using reductive amination are to be determined.
Concept introduction: The conversion of aldehydes and ketones into amines is known as reductive amination. The first step is the formation of imines using aldehydes or ketones and amines. The second step involves the reduction of imine to form amine. The best reagent for this reaction is sodiumcyanoborohydride.
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ORGANIC CHEMISTRY
- In the 1880's, Acetanilide, sold under the name Antifebrin, was widely used as a pain reliever and fever reducer. However, it had many adverse side effects, including cyanosis as a result of methemoglobinemia. The toxic side effects were the result of a small portion of acetanilide being hydrolyzed to aniline. Acetanilide was discontinued and replaced with phenacetin. Later studies show that both acetanilide and phenacetin are metabolized to acetaminophen. This metabolite, which we know as Tylenol, is responsible for the analgesic and antipyretic properties. Part 1: Show a detailed arrow pushing mechanism of the acid catalyzed hydrolysis of acetanilide to aniline Part 2: Propose a synthesis of Acetaminophen from phenol NH NH NH Phenacetin inophen Acetanilide Attach File Browse Local Files Browse Content Collectionarrow_forwardVI. What ammonium salt is formed when each amine is treated with HCI? Draw the structure of the resulting salt. a. -NH2 b. -CH,NHCH3arrow_forwardSynthadotin is a promising anticancer drug in clinical trials. a.Identify the functional groups. b.Classify any amine or amide as 1°, 2°, or 3°. c.At which sites can synthadotin hydrogen bond to another molecule like itself? d. Label two nucleophilic sites. e. Label two electrophilic sites. f. What product is formed when synthadotin is treated with HCl?arrow_forward
- Answer the following questions about atomoxetine, a drug used to treatattention deficit hyperactivity disorder (ADHD). a.) What amides can be reduced to form atomoxetine?b.) What starting materials can be used to form atomoxetine by reductiveamination? Draw all possible methods.c.) What products are formed by Hofmann elimination of atomoxetine?arrow_forwardAlert for not submit AI generated answer. I need unique and correct answer. Don't try to copy from anywhere. Do not give answer in image formet and hand writingarrow_forwardDraw the products formed when each amine is treated with [1] CH3I (excess); [2] Ag2O; [3] Δ. Indicate the major product when a mixture results.arrow_forward
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