Campbell Biology in Focus (2nd Edition)
Campbell Biology in Focus (2nd Edition)
2nd Edition
ISBN: 9780321962751
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece
Publisher: PEARSON
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Chapter 24, Problem 9TYU

FOCUS ON EVOLUTION

In patients infected with nonresistant strains of the tuberculosis bacterium, antibiotics can relieve symptoms in a few weeks. However, it takes much longer to halt the infection, and patients may discontinue treatment while bacteria are still present. How might this result in the evolution of drug-resistant pathogens?

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Antibiotic resistant bacteria have become a major concern for many public health officials. Widespread use of antibiotics has created an evolutionary pressure on infectious bacteria to develop immunity to these medications. The result is an increase in antibiotic resistant microbes, particularly in settings where antibiotics are commonly used, such as hospitals. One strategy public health officials have devised to counteract these infectious microbes is "antibiotic cycling” where specific antibiotics are withdrawn from the market for a period of several years, then reintroduced as another antibiotic is withdrawn.     How would this strategy help limit antibiotic resistance? A. It is impossible for a bacterium to maintain resistance to two antibiotics at once B. When a given antibiotic is not in use, it is an evolutionary disadvantage to carry the unneeded gene C. If a specific antibiotic is removed from the market it is possible to substitute with a related antibiotic such as…
The application of evolution to understanding disease is widespread and productive. What is the benefit of applying Darwinian principles to medical practice?
Acquisition of antibiotic resistance is driven by bacterial exposure to antimicrobial agents (including antibiotics). This is a good example of natural selection; only the most fit (i.e., those with mutations conferring resistance, survive to reproduce and fill the niche with resistance organisms).  Discuss two methods to prevent antimicrobial resistance within your community, but NOT a healthcare setting.
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