Let’s return to Kyle Boulard, whom we met in the previous chapter. After two days in the hospital, Mr. After two days in the hospital, Kyle Boulard has recovered from his acute diabetic crisis and his type 1 diabetes is once again under control. The last update on his chart before he is discharged includes the following:
BP 150/95, HR 75, temperature
Urine: pH 6.9, negative for glucose and
Mr. Boulard is prescribed a thiazide diuretic and an angiotensin converting enzyme (ACE) inhibitor. He is counseled on the importance of keeping his diabetes under control, taking his medications regularly, and keeping his outpatient follow-up appointments.
How do ACE inhibitors reduce blood pressure?
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Anatomy & Physiology (6th Edition)
- Please help me with these questions, more than one answer may be correct for each:1) Which of the following statements are true about the renin-angiotensin-aldosterone axis? A) Angiotensin II stimulates production of aldosterone, which increases sodium reabsorption B) Renin converts angiotensinogen to angotensin I C) Angiotensin II stimulates production of vasopressin, which increases aquaporins in the collecting duct D) Vasopressin decreases thirst E) Renin lowers GFR 2) The purpose of excretion is to A) maintain internal pH B) remove harmful substances C) maintain plasma volume D) maintain osmotic balance E) maintain internal solute concentrationarrow_forwardAn 80-year-old woman was admitted with a diagnosis of hypertension, congestive heart failure, anemia, possible diabetes, and chronic renal failure. Her blood workup shows a BUN level of 58 mg/dL and a plasma creatinine of 6.2 mg/dL. What is the most probable cause of the patient’s elevated urea nitrogen?arrow_forwardA 3-month-old boy is brought to the emergency department because of a 20day history of lethargy. Physical examination shows no other abnormalities. The results of laboratory studies are shown: serum: Na+ 165 mEa/L (N=139-146) Cl- 130 mEq/L (N=95-105) Osmolality 334 mOsmol/kg H2O (N=282-295) urine: specific gravity 1.001 osmolality 117 mOsmol/kg H2O (N>200) He is admitted to the hospital. His urine output is increased. His serum ADH (vasopressin) concentraion is 24 pg/mL (N=1-5); aldosterone and renin concentrations are within the reference ranges. The urine osmolality remains unchanges after administration of 1-deamino-B-arginine vasopressin. An MRI of the brain and pituitary gland shows no abnormalities. Ultrasonography shows normal kidneys. The most likely underlying cause of the findings in this patient is a defect in which of the following?a. angiotensin-converting enzyme b. aquaporin c. 11a-Hydroxylase d. renin e. vasopressin receptorsarrow_forward
- Please provide detail understanding and hand written solutionarrow_forwardAnswer first question. What disorder is affecting this individual?arrow_forwardAdult male suffered myocardial infarction and is currently in cardiogenic shock. Blood pH = 7.25, [HCO3-] = 14 mmol/L, PaCO2 = 38 mmHg. What kind of acid-base imbalance is the patient suffering from? Briefly describe fully how this occurred.arrow_forward
- J.H. is a 12-year-old boy diagnosed several months ago with nephrotic syndrome following postinfectious glomerulonephritis secondary to an episode of pneumococcal pneumonia. He has been coming to the clinic to have his condition monitored and therapies adjusted as needed. At his latest clinic visit, a decrease in urine output, increasing lethargy, hyperventilation, and generalized edema are noted. Trace amounts of protein are detected in J.H.’s urine by dipstick. Blood is drawn for laboratory analysis, and the results are as follows:pH = 7.36 PaCO2 = 33 mm Hg PaO2 = 100 mm Hg HCO3 – = 18 mEq/L Hct = 30% Na+ = 130 mEq/L K+ = 5.4 mEq/L BUN = 58 mg/dl creatinine = 3.9 mg/dl albumin = 2.0 g/dl How would a pneumococcal infection lead to glomerulonephritis? How can glomerulonephritis result in nephrotic syndrome? (Explain the pathophysiology of how pneumococcal infection leads to glomerulonephritis. Explain the pathophysiology of how glomerulonephritis results in nephrotic syndrome.)…arrow_forwardJ.H. is a 12-year-old boy diagnosed several months ago with nephrotic syndrome following postinfectious glomerulonephritis secondary to an episode of pneumococcal pneumonia. He has been coming to the clinic to have his condition monitored and therapies adjusted as needed. At his latest clinic visit, a decrease in urine output, increasing lethargy, hyperventilation, and generalized edema are noted. Trace amounts of protein are detected in J.H.’s urine by dipstick. Blood is drawn for laboratory analysis, and the results are as follows:pH = 7.36 PaCO2 = 33 mm Hg PaO2 = 100 mm Hg HCO3 – = 18 mEq/L Hct = 30% Na+ = 130 mEq/L K+ = 5.4 mEq/L BUN = 58 mg/dl creatinine = 3.9 mg/dl albumin = 2.0 g/dl What additional physical or laboratory findings would be helpful in determining J.H.’s degree of renal impairment? ( List at least 4 additional physical findings/symptoms or laboratory tests that would be helpful in determining the degree of renal impairment.) 2. What would the treatment…arrow_forwardBased on the following information, what is the fraction of the drug that is excreted unchanged in the urine? CLR = 11.2 L/hr Dose = 1000 mg AUC, = 27.9 mg/L x hr %3Darrow_forward
- What is the patient's creatinine clearance given the following data? Serum creatinine 0.6 mg/dL Urine creatinine 102 mg/dL 24 hr urine volume 1650 mL Patient's BSA 1.93 m2 1) 195 mL/min 2) 130 mg/dL 3) 93 mL/min 4) 175 mL/min no references, just homeworkarrow_forwardState four (4) clinical manifestations of Fluid volume excessarrow_forwardMatch the expected results with the following disorder: Beta-thalassemia. A2 Level RDW Serum Fe [Choose] [Choose] Decreased Normal Elevated [Choose]arrow_forward