BIOCHEMISTRY
BIOCHEMISTRY
9th Edition
ISBN: 2818440090622
Author: BERG
Publisher: MAC HIGHER
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Chapter 24, Problem 29P
Interpretation Introduction

Interpretation:

Alkylation of cysteine258 substituted aspartate aminotransferase gives some enzymatic activity.

Concept introduction:

Aspartate aminotransferase (AST) enzyme is found in all the cells of the body, mostly in heart and liver cells. This enzyme is very important in amino acid metabolism because it catalyzes the interconversion of aspartate and glutamate. During the conversion of a-ketoglutarate to glutamate, glutamate undergoes deamination t form ammonium. Reversely, aspartate is formed from OAA, which is used in the Krebs cycle.

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carbons in each of the structures below. For instance, the central carbon of chloromethylbutane (pictured 3. A chiral carbon is a carbon that is single-bonded to four different types of groups. Identify the chiral above) is a chiral carbon. (Can you see how the groups attached to it are all chemically different?) In each of the chiral molecules below, identify all the carbons that are chiral carbons by drawing a circle around each one of them. (a) the carbohydrate glucose H O (b) the carbohydrate fructose CH₂OH 1C H-C-OH 3 HO-C-H 4 H-C-OH 5 H-C-OH 6CH₂OH D-Glucose (linear form) (c) the amino acid leucine O O H3C. HO H H- -OH CH 3 NH2 H- -OH CH₂OH OH
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